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| Evidence and thinking of Wumei Pills for the treatment of Lenvatinib drug-related diarrhea |
| Hits 623 Download times 786 Received:August 10, 2023 |
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| DOI
10.11656/j.issn.1673-9043.2023.06.05 |
| Key Words
Wumei Pill;prescription syndrome;diarrhea;targeted drugs;Treatise on Cold Damage Diseases |
| Author Name | Affiliation | E-mail | | XUE Qin | Department of Oncology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | FANG Wenyan | Department of Oncology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | LU Qiu | The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550001, China | | | CHEN Jun | Department of Oncology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | chenjunjack1988@126.com |
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| Abstract
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| Lenvatinib is a first-line target drug for inoperable liver cancer and can significantly prolong survival. However,diarrhea,as one of the common adverse effects of Lenvatinib,reduces the quality of life of patients,and severe diarrhea may choose to stop the drug temporarily or permanently. For drug-related diarrhea,traditional Chinese medicine (TCM) clinical evidence focuses on enabling patients to tolerate adverse reactions,reduce the frequency of diarrhea,and then ensure targeted drug treatment and improve the quality of life of patients. The course of the disease is generally long,and the symptoms are often manifested as loose or even watery stools,hypothermia,and emotional failure. Based on the dialectical theory,the thesis discusses the treatment of diarrhea by the classic prescription of Treatise on Cold Damage Diseases,which fits the disease mechanism from the multi-dimensional mechanism of yang and yin,reconciles cold and heat,and thins the liver and strengthen the spleen,and obtains many miraculous effects. |
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