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| Systematic review and meta-analysis of integrated traditional Chinese medicine and western medicine forprimary immune thrombocytopenia |
| Hits 611 Download times 691 Received:August 08, 2023 |
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| DOI
10.11656/j.issn.1673-9043.2023.06.08 |
| Key Words
primary immune thrombocytopenia;integrated traditional Chinese and western medicine treatment;systematic review;meta-analysis |
| Author Name | Affiliation | E-mail | | LI Runjie | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Meng | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | NI Runfeng | Graduate School, Tianjin Medical University, Tianjin 300070, China | | | FAN Liwei | Graduate School, Tianjin Medical University, Tianjin 300070, China | | | WANG Aidi | Department of Traditional Chinese Medicine, General Hospital of Tianjin Medical University, Tianjin 300052, China | | | LIU Baoshan | Department of Traditional Chinese Medicine, General Hospital of Tianjin Medical University, Tianjin 300052, China | j33387@qq.com |
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| Abstract
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| [目的] 系统评价中西医结合治疗原发免疫性血小板减少症(ITP)的临床疗效及安全性。[方法] 检索知网(CNKI)、万方、Pubmed和Embase等中英文数据库,筛选中西医结合治疗ITP的随机对照试验(RCT)。依据Cochrane系统评价方法对纳入文献进行质量评价,提取文献基本资料,运用RevMan 5.3 软件进行Meta分析。[结果] 经严格筛选评价,最终纳入20篇文献,共1 538例受试者(观察组782例,对照组756例)。Meta分析结果显示,中西医结合治疗ITP在提高临床疗效[OR=3.42,95%CI(2.55,4.58),P＜0.000 01]、外周血小板计数[WMD=22.88,95%CI(17.48,28.28),P＜0.000 01]、中医证候疗效[OR=5.32,95% CI(2.19,12.89),P=0.000 2]、Treg细胞水平[WMD=0.59,95%CI(0.06,1.12),P=0.03]、CD4+T细胞水平[WMD=4.39,95% CI(2.72,6.06),P＜0.000 01]、远期疗效[OR=3.37,95%CI(1.74,6.50),P=0.000 3],降低中医证候积分[WMD=-5.69,95% CI(-7.30,-4.07),P＜0.000 01]、CD8+T细胞水平[WMD=-3.30,95%CI(-5.07,-1.52),P=0.000 3]、血小板相关抗体IgG(PAIgG)水平[WMD=-8.96,95%CI(-13.77,-4.15),P=0.000 3]、不良反应发生率[OR=0.42,95%CI(0.20,0.89),P=0.02]方面占有优势,明显优于单纯西药,差异有统计学意义(P＜0.05)。[结论] 中西医结合治疗ITP在临床疗效和安全性方面优于单纯西药,但由于研究存在不足,仍需更多高标准、高质量的随机对照试验进一步证实。 |
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