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| Application of graphene oxide and its derivatives in active ingredients of traditional Chinese medicine：a review |
| Hits 615 Download times 554 Received:August 05, 2023 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2023.06.18 |
| Key Words
graphene oxide;composite;active components of traditional Chinese medicine;extraction and separation;nano-drug delivery system;photothermal therapy |
| Author Name | Affiliation | E-mail | | LI Jingya | School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LU Yun | School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | XIAO Yanyu | School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | GAO Chenxia | School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | REN Xiaoliang | School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CHEN Meiling | School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | custard.chen@tjutcm.edu.cn |
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| Abstract
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| The active ingredients of traditional Chinese medicine (TCM) generally have poor solubility,low content,and cumbersome extraction and separation methods,which are not conducive to detection and analysis and poor medicinal properties,limiting their clinical application. New nanomaterials such as Graphene oxide (GO) have been gradually used in the extraction,separation and purification of active components of TCM and anti-tumor therapy due to their unique physicochemical properties,which are expected to improve the clinical application limitations of TCM and promote the clinical development of TCM. Based on the structural properties of GO,this paper summarizes the application of GO in the effective components of TCM,including promoting the dissolution of the effective components of TCM and improving the separation and purification efficiency,improving bioavailability,enhancing drug potency,improving tumor targeting,sustained release,and enhancing curative effect. The existing problems and future development of GO are discussed. The purpose of this study is to provide reference for the development of GO and its derivatives in the field of TCM and the clinical application of active components of TCM. |
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