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| Research progress on the pharmacological effects and mechanism of polysaccharides in traditional Chinese medicine in the treatment of sepsis |
| Hits 186 Download times 241 Received:March 20, 2024 |
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| DOI
10.11656/j.issn.1673-9043.2024.06.13 |
| Key Words
traditional Chinese medicine;polysaccharides;sepsis;mechanism of action;research progress |
| Author Name | Affiliation | E-mail | | LEI Jing | State Key Laboratory of Component Chinese Medicine, Tianjin University of Chinese Medicine, Tianjin 301617, China | | | WANG Xintong | State Key Laboratory of Component Chinese Medicine, Tianjin University of Chinese Medicine, Tianjin 301617, China | | | XU Tongjia | State Key Laboratory of Component Chinese Medicine, Tianjin University of Chinese Medicine, Tianjin 301617, China | | | ZHANG Zhisen | State Key Laboratory of Component Chinese Medicine, Tianjin University of Chinese Medicine, Tianjin 301617, China | | | ZHU Yan | State Key Laboratory of Component Chinese Medicine, Tianjin University of Chinese Medicine, Tianjin 301617, China | | | ZHAO Xin | State Key Laboratory of Component Chinese Medicine, Tianjin University of Chinese Medicine, Tianjin 301617, China | x.zhao26@tjutcm.edu.cn | | FENG Yuxin | State Key Laboratory of Component Chinese Medicine, Tianjin University of Chinese Medicine, Tianjin 301617, China | Fengyn2016@163.com |
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| Abstract
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| Sepsis is defined as life-threatening organ dysfunction caused by an altered host response to infection. Polysaccharides are polymer carbohydrates made of more than 10 monosaccharide molecules of the same or different kinds through glycosidic bonds，which have a wide range of sources，high safety，and low adverse reactions. As one of the key bioactive ingredients of traditional Chinese medicinｅ (TCM)，polysaccharides have multiple biological activities such as antioxidant，immunomodulatory，hypoglycemic，and anti-inflammatory. Although the clinical use of polysaccharides in the treatment of sepsis has not been reported，a series of advances have been made in experimental research recently，which provides the possibility for clinical research. This article reviews the biological activities of TCM polysaccharides，including inhibition of inflammatory response，alleviation of oxidative stress damage，inhibition of apoptosis and pyroptosis，and regulation of immunity of TCM. We also discussed the subsignaling pathways and molecular targets of polysaccharide intervention. This review aims to provide a theoretical basis for the development and clinical application of new polysaccharides-based treatments for sepsis. |
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