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| Nested case-control study on the impact of “Xingnao Kaiqiao” acupuncture on the incidence of stroke-associated pneumonia in elderly patients |
| Hits 148 Download times 153 Received:April 25, 2024 |
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| DOI
10.11656/j.issn.1673-9043.2024.07.04 |
| Key Words
stroke-associated pneumonia;“Xingnao Kaiqiao” acupuncture;nested case-control study;propensity score matching |
| Author Name | Affiliation | E-mail | | XIAO Lu | Emergency Department, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | | | XU Xinyi | Emergency Department, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | | | MIAO Changhong | Emergency Department, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | | | WU Fangying | The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310000, China | | | SONG Yanxing | Emergency Department, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | | | LI Guiwei | Emergency Department, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | | | SHI Cunzhong | Emergency Department, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | shi519@163.com |
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| Abstract
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| [Objective] To investigate the impact of “Xingnao Kaiqiao” acupuncture on the incidence of stroke-associated pneumonia（SAP） in elderly patients with acute cerebral infarction（ACI） in a real-world setting. [Methods] Using a nested case-control study design based on the ACI cohort，propensity score matching（PSM） was employed to balance confounding factors. Matching factors included the National Institutes of Health Stroke Scale（NIHSS） and swallowing difficulties，with a caliper set at 0.01. After successful matching in a 1∶4 ratio，a final cohort of 48 cases and 155 controls was established for the analysis of acupuncture’s impact on the onset of stroke-associated pneumonia（SAP） in elderly ACI patients. Subsequently，logistic regression analysis was employed to investigate the impact of acupuncture on the onset of SAP in the elderly. The analysis also examined the influence of traditional Chinese medicine（TCM） syndrome differentiation on the onset of SAP，as well as the effects of acupuncture on the onset of SAP in ACI patients with different TCM syndromes. [Results] In the end，the study included 48 cases in the experimental group and 155 controls for analysis. After using the “Xingnao Kaiqiao” acupuncture method，the risk of SAP in the elderly decreased by 76%（P＜0.001）. Furthermore，using multifactor logistic regression analysis，it was found that in the three age groups of 60~69，70~79 and ≥80 years old，the “Xingnao Kaiqiao” acupuncture method was a significant factor influencing the occurrence of SAP. The “Xingnao Kaiqiao” acupuncture method significantly reduces the occurrence of SAP in ACI patients with the syndrome of “Yinxu Fengdong”[OR=0.12，95%CI（0.05，0.25），P＜0.000 1]. Additionally，regardless of whether ACI patients were comatose（based on GCS scores），the “Xingnao Kaiqiao” acupuncture method could reduce the occurrence of SAP. [Conclusion] “Xingnao Kaiqiao” acupuncture can influence the occurrence of SAP in ACI patients，especially in ACI patients with “Yinxu Fengdong” syndrome. The preventive effect needs further confirmation through prospective studies. |
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