|
| Inflammatory state of heart failure with preserved ejection fraction and intervention strategies of traditional Chinese medicine based on “deficiency，phlegm，blood stasis and toxin” theory |
| Hits 155 Download times 134 Received:March 07, 2024 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2024.07.11 |
| Key Words
heart failure with preserved ejection fraction;inflammatory state;traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | HE Zhenjie | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SHI Xiaochi | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | ZHAO Yingqiang | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | zhaoyingqiang1000@126.com |
|
| Abstract
|
| Heart failure with preserved ejection fraction（HFpEF） is a common type of heart failure，accounting for about 50% of all heart failure，with high morbidity，rehospitalization rate and mortality. The pathogenesis of HFpEF is more complex and highly heterogeneous than other types of heart failure. In recent years，more and more attention has been paid to the cellular and molecular pathogenesis of HFpEF. A large number of studies have shown that the pathogenesis and disease progression of HFpEF are closely related to inflammation. It involved NO-cGMP-PKG，TGF-β1/Smads，AngⅡ/TGF-β1/Smad2/3，IL-33/ST2L and other signaling pathways. In turn，coronary microvascular endothelial inflammation drives myocardial dysfunction and remodeling. Modern research shows that inflammation is highly similar to the theory of “deficiency，phlegm，blood stasis and poison” of traditional Chinese mediciｎｅ（ＴＣＭ）. Combined with the pathogenic factors，pathological mechanism and clinical manifestations of HFpEF at different stages of the disease，the intervention strategy of TCM is adopted，focusing on supplementing deficiency，dissipating phlegm，removing blood stasis and detoxification. Thus，it can inhibit inflammatory response，reduce myocardial fibrosis，reverse myocardial hypertrophy，protect myocardial cells，inhibit ventricular remodeling，delay the pathological process of HFpEF，alleviate clinical symptoms and improve the quality of life of patients. This article briefly analyzes the pathological changes of HFpEF from the aspects of deficiency，phlegm，blood stasis and toxin in the development of the disease，in order to provide a scientific basis for clinical prevention and treatment of HFpEF. |
|
