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| Modernity and heritage：a dual perspective on STING agonists |
| Hits 91 Download times 93 Received:February 26, 2024 |
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| DOI
10.11656/j.issn.1673-9043.2024.08.14 |
| Key Words
stimulator of interferon genes agonist;traditional Chinese medicine-derived sting agonists;cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway |
| Author Name | Affiliation | E-mail | | ZHAO Feng | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Xue | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Rui | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Yuming | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | wangyuming226@163.com | | LI Yunfei | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | liyunfei@tjutcm.edu.cn |
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| Abstract
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| The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING) signaling pathway is a pivotal regulator within the immune system and holds significant potential for research and application in cancer immunotherapy. Upon activation of the STING protein by this pathway,it promotes the production of Type I interferons,which subsequently affects the maturation of dendritic cells and enhances the cytotoxic capabilities of T lymphocytes and natural killer cells,thereby bridging innate and adaptive immune responses. This review focuses on the regulatory effects of chemical STING agonists and the modulation of the cGAS-STING signaling pathway by components derived from traditional Chinese medicine(TCM). These studies not only elucidate the molecular mechanisms of STING agonists but also provide a theoretical foundation for the development of novel immunomodulatory agents. Furthermore,this review discusses the potential integration of TCM components with modern drug design,offering new perspectives and strategies for future research in immunotherapy. |
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