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| Study on the correlation of serum AMPKα1 levels in patients with diabetic heart disease of different evidence types |
| Hits 95 Download times 44 Received:May 16, 2024 |
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| DOI
10.11656/j.issn.1673-9043.2024.09.02 |
| Key Words
diabetic heart disease;serum AMPKα1 level;Chinese medicine evidence type |
| Author Name | Affiliation | E-mail | | LU Xiaoxi | School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Xuan | Drug Clinical Trial Base, Tianjin Fourth Central Hospital, Tianjin 300140, China | | | LI Huanming | Department of Cardiology, Tianjin Fourth Central Hospital, Tianjin 300140, China | 1994235725@qq.com |
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| Abstract
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| [Objective] To investigate the correlation between serum adenosine mono phosphate(AMP)-activated protein kinase(AMPK) levels and disease injury status in patients with diabetic heart disease(DHD) and the distribution pattern in different Chinese medicine certificates. [Methods] Thirty cases each of DHD patients,type 2 diabetes mellitus patients(DM) in the Department of Endocrinology and healthy volunteer population(HC) hospitalized in the Department of Cardiology of our hospital from October 2022 to January 2023 were included to compare the differences in serum AMPKα1 levels among the three groups,and the DHD group was divided into the group of qi and yin deficiency with blood stasis,the group of cardiac and renal yin deficiency with blood stasis,and the group of yin and yang deficiency with blood stasis according to the identification of traditional Chinese medicine(TCM) evidence. Spearman's correlation analysis was used to study the differences between adenosine activated protein kinase alpha 1(AMPKα1) and glucose and lipid metabolism including fasting plasma glucose(FPG),glycated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),myocardial injury including B-type natriuretic peptide(BNP),lactate Dehydrogenase(LDH),Creatine Kinase-Myocardial Band(CK-MB),and echocardiographic indices of cardiac function,such as right atrial diameter(RAD),left ventricular internal diastolic diameter(LVIDd),interventricular septal thickness(IVS),left ventricular posterior wall thickness(LVPW),etc. In addition,the DHD group was classified according to the Chinese medicine diagnosis,and the DHD group was divided into the heart and kidney yin and yang deficiency group and the stasis group. thickness(LVPW),and so on. [Results] Serum AMPKα1 was significantly lower in the disease group than in the HC group(P<0.01). serum AMPKα1 levels in the DHD group showed a high negative correlation with HbA1c(r=-0.811,P<0.001),a moderate negative correlation with TyG(r=-0.743,P<0.001),a low negative correlation with blood lipid metabolites(0.3<r<0.5,P<0.05),low negative correlation with cardiac function chamber movement LVIDd,LVPW,IVS(r=-0.421 P=0.018,r=-0.433 P=0.015),r=-0.434 P=0.015),moderate negative correlation with RAD(r=-0.694 P<0.001),and no correlation with the indicators of myocardial damage. Among the DHD patterns,the AMPKα1 level in the pattern of qi and yin deficiency with stasis pattern was lower than that in other patterns(P<0.05). [Conclusion] AMPKα1 levels in DHD patients were lower than those in healthy people and were negatively correlated with glucose and lipid metabolism and the degree of myocardial chamber movement. There were statistically significant differences in AMPKα1 levels in patients with different TCM patterns,which may provide an objective basis for the clinical diagnosis of diabetic heart disease. |
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