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| Recent advances in the dual regulation of microglia in ischemic stroke and the modulatory role of traditional Chinese medicine |
| Hits 63 Download times 34 Received:June 10, 2024 |
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| DOI
10.11656/j.issn.1673-9043.2024.09.08 |
| Key Words
microglia;ischemic stroke;M1/M2 phenotype;traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | PENG Zhen | Institute of Chinese Medicine, Tianjin University of Chinese Medicine, Tianjin 301617, China | | | ZHANG Han | Institute of Chinese Medicine, Tianjin University of Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Component-based Chinese Medicine, Tianjin University of traditional Chinese medicine, Tianjin 301617, China | | | LI Xinyue | Institute of Chinese Medicine, Tianjin University of Chinese Medicine, Tianjin 301617, China | | | MA Yaolei | Institute of Chinese Medicine, Tianjin University of Chinese Medicine, Tianjin 301617, China | | | WEI Mingyan | Institute of Chinese Medicine, Tianjin University of Chinese Medicine, Tianjin 301617, China | | | LI Lin | Institute of Chinese Medicine, Tianjin University of Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Component-based Chinese Medicine, Tianjin University of traditional Chinese medicine, Tianjin 301617, China | lilintcm@126.com | | LI Nan | Institute of Chinese Medicine, Tianjin University of Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Component-based Chinese Medicine, Tianjin University of traditional Chinese medicine, Tianjin 301617, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | linan@tjutcm.edu.cn |
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| Abstract
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| Ischemic stroke is a common cerebrovascular disease,usually caused by cerebral blood supply disorders leading to insufficient oxygen supply or ischemic necrosis of brain tissue,which seriously affects patient health and brings a heavy burden to the social economy. Ischemic necrosis of brain tissue can cause various neurological disorders,and recovery is not an easy task. In recent years,establishing an immune environment conducive to ischemic stroke tissue repair by regulating immunity has become a current research hotspot. Microglia are innate immune cells widely distributed in the central nervous system(Central Nervous System,CNS),capable of dynamically monitoring the brain microenvironment of tissue damage after ischemic stroke,and are activated into two states:classical activation(M1 phenotype) and alternative activation(M2 phenotype). They are a double-edged sword in the neural repair of ischemic stroke. The M1 and M2 phenotypes of microglia exhibit pro-inflammatory and anti-inflammatory properties,respectively. Promoting the polarization phenotype of microglia from M1 to M2 helps to suppress neuroinflammation and is an important intervention strategy for treating ischemic stroke. Therefore,this article summarizes the potential mechanisms of M1/M2 phenotype transformation of microglia after ischemic stroke,as well as the regulation of polarization process by traditional Chinese medicine,providing new ideas for discovering and exploring potential immunotherapies. |
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