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| Research progress on pharmacogenomics and related signalling pathways of traditional Chinese medicine in treating nasopharyngeal carcinoma| |
| Hits 95 Download times 24 Received:May 01, 2024 |
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| DOI
10.11656/j.issn.1673-9043.2024.11.11 |
| Key Words
traditional Chinese medicine;nasopharyngeal carcinoma;signal pathway;pharmacogenomic |
| Author Name | Affiliation | E-mail | | BAO Jingjing | College of Integrative Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | FAN Zhichao | College of Integrative Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | XIONG Hui | Acupuncture Encephalopathy Department, Tianjin Nankai district Traditional Chinese Medicine Hospital, Tianjin 301617, China | | | SANG Zifan | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Jing | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YANG Jian | National Key Laboratory of Chinese Medicine Modernization, Key Laboratory of Chinese Pharmacology of the Ministry of Education, Tianjin 301617, China | | | ZHANG Jianling | College of Integrative Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | JIANG Ru | College of Integrative Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | rujiang66@126.com |
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| Abstract
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| China is the region with the highest incidence of nasopharyngeal carcinoma in the world. Early onset of nasopharyngeal carcinoma is insidious and difficult to detect, while late-stage radiotherapy and chemotherapy have poor efficacy. Genomic studies have showed that nasopharyngeal carcinoma is a type of cancer with unique genomic characteristics, which is closely related to poor clinical treatment. Current domestic and international research shows that traditional Chinese medicine（TCM） mainly regulates 158 genes, including caspase-3, Bcl-2, Bax, PI3K, Akt, mTOR, ERK1/2, PARP, MMP-9, CyclinD1, PCNA and E-cadherin, and has unique advantages in inhibiting nasopharyngeal carcinoma cell proliferation, migration, invasion, inducing autophagy and promoting apoptosis. And related key signaling pathways are involved in this process, mainly including RAS, PI3K, Wnt, NF-κB signaling pathway, as well as STAT, TGF-β, Notch, Hippo, AMPK/mTOR and other signal pathways. This article comprehensively and systematically summarizes and analyzes the genomics of nasopharyngeal carcinoma, the gene landscape and signal pathway enrichment of TCM's anti nasopharyngeal carcinoma efficacy, which will provide new clues and ideas for the research and clinical treatment of TCM's anti nasopharyngeal carcinoma. |
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