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| Research progress on the mechanism of traditional Chinese medicine regulating endoplasmic reticulum stress-related pathways to improve liver lipid metabolism disorders |
| Hits 86 Download times 40 Received:May 08, 2024 |
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| DOI
10.11656/j.issn.1673-9043.2024.11.13 |
| Key Words
liver lipid metabolism disorder;endoplasmic reticulum stress;traditional Chinese medicine;chronic inflammation;oxidative stress;insulin resistance |
| Author Name | Affiliation | E-mail | | HE Yajie | The First Clinical School, Heilongjiang University of Chinese Medicine, Harbin 150040, China | | | DU Likun | Department of Endocrinology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China | dulikun@hljucm.net | | REN Na | Department of Endocrinology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China | | | LI Jiarui | The First Clinical School, Heilongjiang University of Chinese Medicine, Harbin 150040, China | |
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| Abstract
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| Liver is an important organ of lipid metabolism. Hepatic steatosis is not only a direct threat to liver health, but also closely related to obesity, insulin resistance and cardiovascular diseases. Endoplasmic reticulum stress is a protective stress response of cells, but excessive endoplasmic reticulum stress can destroy the intracellular environment, affect liver lipid metabolism, and then lead to diseases. Traditional Chinese medicine(TCM) can reduce chronic inflammation, oxidative stress and insulin resistance by regulating endoplasmic reticulum stress-related pathways, and thus improve liver lipid metabolism disorders. This article summarizes recent domestic and foreign literature, and reviews the current research progress of Active components in Chinese herb in preventing and treating liver lipid metabolism disorders based on endoplasmic reticulum stress-related pathways. It aims to provide a theoretical basis for the prevention and treatment of liver lipid metabolism disorders with TCM, and offer a valuable reference for the research and development of new clinical drugs. |
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