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| Mechanism of aromatic resuscitation herbs on blood brain barrier regulation in stroke |
| Hits 62 Download times 33 Received:August 29, 2024 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2024.12.11 |
| Key Words
aromatic resuscitation herbs;blood-brain barrier;stroke |
| Author Name | Affiliation | E-mail | | LI Tiantian | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WU Meirong | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Lin | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | lilintcm@126.com | | ZHANG Han | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | zhanghan0023@126.com |
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| Abstract
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| Stroke is an acute diseases of the nervous system,is the world's one of the leading causes of death and long-term disability. After stroke,the blood-brain barrier will be damaged,followed by brain damage,nerve damage,and increased risk of bleeding and other serious consequences. Aromatic resuscitation herbs have a history of thousands of years in the treatment of stroke,which can play the characteristics of light and buoyance of drugs to achieve the role of resuscitating the brain. Modern studies have found that aromatic resuscitation herbs can not only restore the permeability of the blood-brain barrier after damage,but also promote drugs to enter the brain through the blood-brain barrier to play a role. The main mechanisms involved are regulating the expression of tight junction proteins and neurotransmitters,acting on transporters,and regulating inflammatory responses. Therefore,this article reviews the mechanism of aromatic resuscitation herbs in regulating the blood-brain barrier after stroke and the development of orifices combined with modern new preparations. |
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