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| Research progress on traditional Chinese medicine treatment of chronic obstructive pulmonary disease based on the Nrf2/ARE signaling pathway |
| Hits 562 Download times 281 Received:August 20, 2024 |
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| DOI
10.11656/j.issn.1673-9043.2024.12.13 |
| Key Words
chronic obstructive pulmonary disease;Nrf2;antioxidant;traditional Chinese medicine |
| Author Name | Affiliation | | QIU Jianyong | Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou 510095, China | | ZHANG Jianjun | Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou 510095, China
Guangdong Provincical Key Laboratory of Research and Development in Traditional Chinese Medicine, Guangzhou 510095, China | | HONG Duyun | Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou 510095, China | | LI Wenbing | Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou 510095, China | | FENG Suifen | Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou 510095, China | | CHENG Liangkai | Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou 510095, China |
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| Abstract
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| Oxidative stress is a state caused by an imbalance between oxidation and antioxidant defense,which can lead to severe cellular damage and play a driving role in the progression and deterioration of chronic obstructive pulmonary disease(COPD). The NF-E2-related factor 2(Nrf2)/antioxidant response element(ARE) signaling pathway is one of the most important antioxidant signaling pathways in the human body for maintaining redox balance. Numerous studies have shown the effectiveness of traditional Chinese medicine(TCM) in improving the prognosis of COPD and lung function by activating Nrf2-related signaling pathways. However,there is a lack of summarization and discussion regarding the mechanisms of traditional Chinese medicine in COPD treatment based on the Nrf2/ARE signaling pathway. Therefore,this article provides an overview of recent research on the Nrf2/ARE signaling pathway and the research progress of TCM in the treatment of COPD based on Nrf2,aiming to provide insights for clinical and basic research on the prevention and treatment of COPD using TCM. |
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