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| Meta-analysis of acupuncture for mild to moderate Alzheimer’s disease |
| Hits 684 Download times 276 Received:October 13, 2024 |
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| DOI
10.11656/j.issn.1673-9043.2025.01.10 |
| Key Words
acupuncture;Alzheimer’s disease;meta-analysis;trial sequential analysis |
| Author Name | Affiliation | E-mail | | YU Yi | School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHU Zheng | School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Yingdong | School of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Mingxing | Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | XI Qiang | Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | QIU Jiwen | Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Xinju | Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | REN Haiyan | Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | GUO Yi | Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | guoyi_168@163.com |
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| Abstract
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| [Objective] To assess the efficacy and safety of acupuncture in the treatment of mild to moderate Alzheimer’s disease using meta-analysis. [Methods] Literature related to acupuncture for Alzheimer’s disease published from the establishment of the database to 5 January 2024 in CNKI，Wan Fang，VIP，China Biomedical Literature Database，PubMed，Cochrane Library，Web of science and EMbase was searched. The quality of the included literature was evaluated using RoB 2.0 tool，RevMan 5.3 software for meta-analysis，Stata 17.0 software for risk of bias analysis，and TSA 0.9 software for trial sequential analysis. [Results] A total of 17 randomised controlled trials including 1 103 patients with mild-to-moderate Alzheimer’s disease were included. Interventions included manual acupuncture，electroacupuncture，and warm acupuncture. The results of the meta-analysis showed that compared with control group，acupuncture treatment significantly improved patients’ MMSE score[MD=1.92， 95%CI（1.29，2.56），P<0.000 01]，ADAS-cog score[MD=-3.29，95%CI（-3.96，-2.62），P<0.000 01] and QOL-AD score[MD=2.97，95%CI（1.49，4.44），P<0.000 1]. Risk of bias analysis indicated a low likelihood of publication bias（P=0.252）. Trial sequential analysis showed that the number of cases in the included studies met the required sample size and the results were reliable. [Conclusion] Acupuncture for mild-to-moderate Alzheimer’s disease can significantly improvepatients’ cognitive function and quality of life，and more high-quality randomised controlled trials are needed to further validate this in the future. |
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