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| A new approach to treating polycystic ovary syndrome by improving mitochondrial function with warm medicine from the perspective of phlegm fluid |
| Hits 524 Download times 289 Received:September 07, 2024 |
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| DOI
10.11656/j.issn.1673-9043.2025.01.13 |
| Key Words
polycystic ovary syndrome;mitochondrion;traditional Chinese medicine;phlegm fluid |
| Author Name | Affiliation | E-mail | | ZHUANG Zixun | The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China
The Chinese Clinical Medicine Innovation Center of Obstetrics, Gynecology, and Reproduction in Jiangsu Province, Nanjing 210029, China | | | SHANG Tingting | The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China
The Chinese Clinical Medicine Innovation Center of Obstetrics, Gynecology, and Reproduction in Jiangsu Province, Nanjing 210029, China | | | MA Hua | The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China
The Chinese Clinical Medicine Innovation Center of Obstetrics, Gynecology, and Reproduction in Jiangsu Province, Nanjing 210029, China | | | GE Xian | The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China
The Chinese Clinical Medicine Innovation Center of Obstetrics, Gynecology, and Reproduction in Jiangsu Province, Nanjing 210029, China | | | REN Qingling | The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China
The Chinese Clinical Medicine Innovation Center of Obstetrics, Gynecology, and Reproduction in Jiangsu Province, Nanjing 210029, China | yfy0047@njucm.edu.cn |
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| Abstract
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| Polycystic ovary syndrome（PCOS），often characterized by obesity，frequently corresponds to spleen deficiency and phlegm dampness syndrome. According to Jin Gui Yao Lue，patients with phlegm and fluid retention should be treated with warming medicines. The use of these warming medicines aims to enhance the warming effect of kidney yang，thereby improving spleen function，promoting water metabolism，and facilitating the transformation and warming of phlegm and fluids. Mitochondria，the primary site for oxidative phosphorylation and ATP production，serve as the cell’s energy source. Their functions，including oxidative energy supply，metabolic regulation，protein synthesis，maintenance of cellular functions，and facilitation of energy metabolism，are akin to the effects of traditional Chinese medicine（TCM） yang qi in promoting growth，development，organ function，as well as the production and circulation of blood and body fluids. This article presents a novel perspective on treating phlegm-dampness type PCOS by enhancing mitochondrial function with warm medicine，seeking to provide a foundation and direction for interpreting the material basis of TCM and the clinical application of warm medicine in PCOS. |
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