|
| Effects of abdominal acupressure on food intake and colonic PYY and GLP-1 expression in rats with simple obesity model |
| Hits 4 Download times 0 Received:October 05, 2024 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2025.02.08 |
| Key Words
abdominal acupressure;simple obesity;PYY;GLP-1;food intake;body weight |
| Author Name | Affiliation | E-mail | | HUANG Caiyin | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Medical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | TAN Tao | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Medical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China | | | LI Huanan | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Medical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China
The Third Level Laboratory of Biological Effects of Tuina Techniques, National Administration of Traditional Chinese Medicine, Tianjin 300193, China | lihuanan1984@126.com | | MA Fei | Scientific Research Department, Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin 300120, China | | | AN Chengfei | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Medical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | BIAN Mingzhen | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Medical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | NING Jing | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Medical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | |
|
| Abstract
|
| [Objective] To explore the effect of abdominal nudging on the expression of colonic PYY and GLP-1 in the model of simple obese rats,and to analyze its possible mechanism of action.[Methods] 24 SD male rats were randomly divided into 3 groups:blank group,model group and nudging group,8 rats each. The model group and the nudging group were given homemade high-fat feed to establish simple obesity animal model. In the nudging group,abdominal nudging was applied to the abdomen[rubbing Zhongwan(RN12) and pushing Renmai(CV)] for 20 min/times,1 day for 14 d. The model group was only given the same time restraint as that of the nudging group. The blank group was not modeled or intervened. At the end of the intervention,the body mass,food intake,body length and Lee's index of the rats in the three groups were examined to evaluate the changes in their physiological indexes. Enzyme-linked immunosorbent assay(ELISA) was used to examine the levels of Peptide YY(PYY) and Glucagon Like Peptide-1(GLP-1) in the intestines of rats. HE staining was applied to observe the morphological and structural changes of intestinal colon tissue.[Results] Compared with the rats before and after their own,the body mass and food intake of the nudging group decreased(P<0.01);compared with the model group,the fat coefficient of the nudging group decreased(P<0.01),and the expression of PYY and GLP-1 was elevated(P<0.01);the HE test showed that the structure of the colonic glands of the model group was disorganized,with crypts shrinking and deforming,and the number of cup cells was small,and there was infiltration of chronic inflammatory cells. After abdominal acupressure,the morphology of colon tissue tended to return to the normal state.[Conclusion] Abdominal acupressure may improve the expression of intestinal PYY and GLP-1,regulate the gastrointestinal function,inhibit appetite,and create a negative energy balance of intake-consumptionin purely obese rats to achieve the effect of fat reduction and weight loss. |
|
|
|
|
|
