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| The role of NK cells in sepsis and the potential of traditional Chinese medicine to regulate its function in the prevention and treatment of sepsis |
| Hits 6 Download times 1 Received:September 28, 2024 |
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| DOI
10.11656/j.issn.1673-9043.2025.02.13 |
| Key Words
sepsis;natural killer cells;immunotherapy;traditional Chinese medicine;inflammation |
| Author Name | Affiliation | E-mail | | ZHANG Yue | State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SHANG Ting | State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SHEN Ru | State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Yuhong | State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | liyuhong@tjutcm.edu.cn | | FENG Yuxin | State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | fengyn2016@163.com |
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| Abstract
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| Sepsis is a systemic inflammatory response syndrome caused by the invasion of pathogenic microorganisms such as bacteria,and the dysregulation of innate immune response is one of the significant factors leading to the occurrence and development of sepsis. Natural killer cells(NK) are an important part of innate immune cells that can recognize and attack abnormal cells in a variety of ways,playing a role in fighting infection and maintaining immune balance. A number of studies have shown that the quantity and cytotoxic activity of NK cells are closely related to the process of sepsis,and many traditional Chinese medicines(TCM) that can effectively improve sepsis also have a regulatory effect on NK cells. Therefore,this review mainly focused on the role of NK cells in sepsis,and discussed the strategy of sepsis immunotherapy targeting NK cells and the prospect of TCM regulating NK cell-related functions in the prevention and treatment of sepsis. |
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