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| Clinical efficacy observation of Yangxinshi tablets in improving exercise tolerance in patients with stable angina pectoris in coronary heart disease |
| Hits 647 Download times 247 Received:December 10, 2024 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2025.03.03 |
| Key Words
stable angina pectoris in coronary heart disease;Yangxinshi tablets;cardiopulmonary exercise test;exercise tolerance;cardiac rehabilitation |
| Author Name | Affiliation | E-mail | | WU Xudong | Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Yu | Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | ZHENG Ying | Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | ZHAO Guoyuan | Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | SU Quan | Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | GE Zhao | Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | REN Silin | Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Xianliang | Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | xlwang1981@126.com |
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| Abstract
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| [Objective] To explore the clinical efficacy of Yangxinshi tablets in improving exercise tolerance on stable angina pectoris(SAP). [Methods] Forty patients were randomly divided into a control group and a treatment group,20 patients per group. On the basis of Western medicine treatment,the control group was added with trimetazidine(20 mg/Tid),and the treatment group was added with Yangxinshi tablets(3 tablets/Tid),each group had 4 weeks of treatment,the visit points were at the time of enrollment and 4 weeks after treatment. The main therapeutic indicator was the peak VO2/kg oxygen uptake during cardiopulmonary exercise testing,the secondary therapeutic indicators were the METs@AT,Peak METs,Peak VO2/HR,VO2/WR slope,traditional Chinese medicine(TCM) syndrome score,improvement rate of angina pectoris,SAP scale score(SAQ),GAD-7 anxiety screening scale score,and PHQ-9 depression scale score. The safety indicators were the basic vital signs,blood routine,liver and kidney function,adverse events,etc. [Results] Compared with the enrollment,the treatment group and control group had shown an increase in Peak VO2/kg,METs@AT,Peak METs,Peak VO2/HR,VO2/WR slope and SAQ scores;had shown a decrease in TCM syndrome score,GAD-7 anxiety screening scale score,and PHQ-9 depression scale score at 4 weeks after treatment(P＜0.01). Compared with the control group,the treatment group had shown an increase in Peak VO2/kg METs@AT,Peak METs,Peak VO2/HR,and VO2/WR slopes(P＜0.05),physical activity restriction(PL) in SAQ scores(P＜0.01);had shown a decrease in TCM syndrome score(P＜0.01) at 4 weeks after treatment. After 4 weeks of treatment,the improvement rates of angina pectoris in the treatment group and the control group were 75% and 40%(P＜0.05). [Conclusion] On the basis of conventional Western medicine treatment,the addition of Yangxinshi tablets can effectively improve the exercise tolerance level,clinical symptoms and quality of life,reduce their anxiety and depression,and have good safety. |
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