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| Pharmacological mechanisms of traditional Chinese Medicine in the treatment of knee osteoarthritis |
| Hits 496 Download times 248 Received:December 28, 2024 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2025.03.11 |
| Key Words
knee osteoarthritis;traditional Chinese medicine;pharmacology;molecular mechanism |
| Author Name | Affiliation | E-mail | | NIU Puyu | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | LIU Yaoyuan | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | CHEN Jixin | Shaoxing Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Shaoxing 312000, China | | | FENG Huichuan | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | YU Weijie | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | LIU Aifeng | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | draifeng@163.com | | ZHAO Meng | Tianjin Heping District Traditional Chinese Medicine Hospital, Tianjin 300050, China | 394536675@qq.com |
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| Abstract
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| Knee osteoarthritis(KOA) is a common degenerative joint disease encountered in clinical practice,characterized by recurrent episodes and a high disability rate,which significantly impacts patients' quality of life. Previous studies have demonstrated that traditional Chinese medicine(TCM) possesses unique advantages in treating KOA,with definite efficacy and high safety. However,the specific mechanisms underlying the therapeutic effects of TCM in KOA remain to be explored. The research paradigm of network pharmacology,characterized by "multi-component,multi-target,multi-pathway,and multi-disease," aligns well with the theory of "syndrome differentiation and treatment" in TCM,offering a new approach to unravel the mechanisms of TCM in treating KOA. This paper systematically reviews the application of network pharmacology in elucidating the pharmacological material basis and potential molecular mechanisms of TCM in treating KOA and anticipates future research directions in this field. Additionally,it provides a new perspective and a powerful tool for unveiling the scientific connotations of TCM in treating KOA,further promoting the modernization of TCM. |
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