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| Based on the pathogenesis of “glucotoxicity damaging the kidney，and the accumulation of minor to significant”：exploring the mechanisms of “metabolic memory” formation in diabetic kidney disease from both traditional Chinese and Western medical perspectives |
| Hits 620 Download times 231 Received:October 16, 2024 |
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| DOI
10.11656/j.issn.1673-9043.2025.03.12 |
| Key Words
diabetic kidney disease;metabolic memory;glucotoxicity damaging the kidney, and the accumulation of minor to significant |
| Author Name | Affiliation | E-mail | | LI Hanzhou | College of Integrated Traditional Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WEN Weibo | The First Clinical Medical College of Yunnan University of Chinese Medicine, Kunming 650500, China | | | KONG Xiangying | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China | | | XING Liwei | The First Clinical Medical College of Yunnan University of Chinese Medicine, Kunming 650500, China | | | LYU Shuquan | Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine in Hebei Province, Cangzhou 061001, China | | | BIAN Yuhong | College of Integrated Traditional Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | bianyuhong_2012@163.com | | CUI Huantian | The First Clinical Medical College of Yunnan University of Chinese Medicine, Kunming 650500, China | 1762316411@qq.com |
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| Abstract
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| Diabetic kidney disease(DKD) is one of the microvascular complications of diabetes and is also a major cause of end-stage renal disease(ESRD). "Metabolic memory" refers to the phenomenon where the high blood glucose state in the early stages of diabetes continues to influence and increase the risk of complications such as DKD,even after blood sugar is controlled later. This review summarizes the mechanisms related to "metabolic memory" in DKD,including cellular senescence,inflammatory responses,and oxidative stress,and discusses the role of epigenetic modifications in this process. In addition,starting from the theory of "Glucotoxicity" in traditional Chinese medicine(TCM),this paper proposes the pathogenic concept of "Glucotoxicity damaging the kidney,and the accumulation of minor to significant",and explores the potential role of TCM in improving the "metabolic memory" associated with DKD. It also proposes new strategies for the integration of Chinese and Western medicine in the treatment of DKD. Finally,this paper looks forward to future research directions,including a deeper understanding of the "metabolic memory" mechanism,identifying related targets,and exploring the dynamic laws of disease intervention by TCM,in order to provide a reference direction for subsequent research. |
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