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Research progress on the regulation of inflammatory reaction signaling pathways by traditional Chinese medicine to prevent pulmonary hypertension

Hits 436 Download times 187 Received:December 05, 2024

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DOI 10.11656/j.issn.1673-9043.2025.04.10

Key Words traditional Chinese medicine;pulmonary hypertension;inflammatory reaction;signaling pathway

Author Name Affiliation E-mail
LI Mingwei Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
WANG Shuai Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
WANG Lin Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
ZHANG Zeyu Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
WANG Ci Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
WANG Xianliang Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
MAO Jingyuan Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China jymao@126.com

Abstract

Pulmonary hypertension（PH） is a clinical syndrome of elevated pulmonary vascular resistance and pulmonary artery pressure caused by a variety of etiological factors，which can lead to increased right ventricular afterload，resulting in right heart failure or even death. The pathogenesis of PH includes inflammatory response，imbalance of vasoactive substances，and abnormal energy metabolism，etc. Inflammatory response is widely involved in the development of PH，which is considered to be a potential key target for the treatment of PH. In recent years，traditional Chinese medicine（TCM） has shown significant efficacy in the treatment of PH，and related multi-component，multi-pathway and multi-target mechanism studies have been widely carried out. This article reviews the progress of research on four inflammatory response signaling pathways，including the NF-κB signaling pathway，MAPK signaling pathway，NLRP3 signaling pathway，and the JAK/STAT signaling pathway，to provide references for the subsequent clinical and basic studies on TCM in the prevention and treatment of PH.

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