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| Research progress on mitochondrial energy metabolism disorders and the role of traditional Chinese medicine regulation in depression |
| Hits 382 Download times 233 Received:January 10, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2025.04.13 |
| Key Words
depression;mitochondrion;energy metabolism;traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | ZHAO Shengjun | College of Pharmacy, Shandong First Medical University, Jinan 250000, China
College of Pharmacy, Jining Medical University, Rizhao 276826, China | | | Yang Qian | College of Pharmacy, Jining Medical University, Rizhao 276826, China | | | GAO Lina | College of Pharmacy, Jining Medical University, Rizhao 276826, China | linagao228@126.com |
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| Abstract
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| Depression is a common mental illness with complex pathogenesis，while has not yet to be fully elucidated. Particularly，it is difficult to fully explain the low motivation symptoms often exhibited by patients through a single mechanism. The hypothesis of mitochondrial energy metabolism disorders provides a new perspective to understand the symptoms of low motility. Traditional Chinese medicine exerts antidepressant effect by harmonizing the liver and spleen，and its modern scientific explanation are closely related to the regulation of mitochondrial function. This article aims to review the latest research progress on mitochondrial energy metabolism disorders in the pathological mechanism of depression，and to explore in depth the current research status of traditional Chinese medicine on regulating mitochondrial energy metabolism disorders for antidepressant treatment. Through reviewing relevant literature from the past 5 years，we found that patients with major depression are accompanied by significant mitochondrial structural abnormalities. Moreover，mitochondrial energy metabolism disorders are closely related to neurotransmitter transmission disorders，impaired neuroplasticity，oxidative stress damage and inflammation，disruption of the microbiota-gut-brain axis，and neuronal cell death，and are key factors in the occurrence and development of depression. Commonly used antidepressant Chinese medicines such as Chaihu，Baishao，and Curcuma longa can directly repair mitochondrial structure and function，as well as indirectly affect mitochondrial energy metabolism. However，their pharmacological substance basis and molecular targets need to be further explored. This article aims to provide scientific basis and reference for deepening the understanding of the pathogenesis of depression and developing innovative treatment strategies targeting mitochondria. |
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