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| Research progresses on molecular pathogenesis of myocardial fibrosis and treatment drugs from traditional Chinese medicine |
| Hits 426 Download times 255 Received:February 16, 2025 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2025.05.12 |
| Key Words
myocardial fibrosis;pathogenesis;signaling pathway;traditional Chinese medicine;research progress |
| Author Name | Affiliation | E-mail | | ZHOU Fengjie | Tianjin University of Traditional Chinese Medicine, State Key Laboratory of Components of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Lin | Tianjin University of Traditional Chinese Medicine, State Key Laboratory of Components of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin 301617, China | | | DU Siqi | Tianjin University of Traditional Chinese Medicine, State Key Laboratory of Components of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin 301617, China | | | BAI Liding | Tianjin University of Traditional Chinese Medicine, State Key Laboratory of Components of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin 301617, China | | | QI Yulin | Tianjin University of Traditional Chinese Medicine, State Key Laboratory of Components of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Yuhong | Tianjin University of Traditional Chinese Medicine, State Key Laboratory of Components of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin 301617, China | liyuhong@tjutcm.edu.cn | | LEI Wei | Tianjin University of Traditional Chinese Medicine, State Key Laboratory of Components of Traditional Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin 301617, China | l_wei8910@163.com |
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| Abstract
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| myocardial fibrosis（MF） is a common pathological change in the development of multiple cardiovascular diseases，characterized by abnormal proliferation of cardiac fibroblasts（CFs） and extracellular matrix（ECM） over deposition and abnormal distribution. Although MF seriously endangers people’s health，there are no specific therapeutic drugs and methods for this pathological change at present. In this paper，the pathological mechanism，molecular mechanism and biological signaling pathway of MF are systematically reviewed，and the Chinese medicines that have the effect of improving myocardial fibrosis in clinical and basic studies are summarized，which provides a scientific research basis for the subsequent development of novel anti-MF therapeutic drugs. |
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