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| Research progress on the pharmacological effects of alkaloids in the treatment of type 2 diabetes mellitus |
| Hits 532 Download times 254 Received:November 05, 2024 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2025.05.13 |
| Key Words
type 2 diabetes;traditional Chinese medicine;alkaloids;insulin resistance;mechanism of action |
| Author Name | Affiliation | E-mail | | YANG Yuanjiao | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CHEN Jinpeng | Tianjin Institute of Materia Medica, Heguang Chinese Medicine Technology(Tianjin) Co., Ltd., Tianjin 300462, China
Tianjin Key Laboratory of Quality Markers of Traditional Chinese Medicine, Tianjin 300462, China
National Key Laboratory of Drug Druggability Evaluation and Systematic Transformation, Tianjin 300462, China | | | LIU Yi | Tianjin Institute of Materia Medica, Heguang Chinese Medicine Technology(Tianjin) Co., Ltd., Tianjin 300462, China
Tianjin Key Laboratory of Quality Markers of Traditional Chinese Medicine, Tianjin 300462, China
National Key Laboratory of Drug Druggability Evaluation and Systematic Transformation, Tianjin 300462, China | | | GAI Xiaohong | Tianjin Institute of Materia Medica, Heguang Chinese Medicine Technology(Tianjin) Co., Ltd., Tianjin 300462, China
Tianjin Key Laboratory of Quality Markers of Traditional Chinese Medicine, Tianjin 300462, China
National Key Laboratory of Drug Druggability Evaluation and Systematic Transformation, Tianjin 300462, China | | | WANG Fanfan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | TIAN Chengwang | Tianjin Institute of Materia Medica, Heguang Chinese Medicine Technology(Tianjin) Co., Ltd., Tianjin 300462, China
Tianjin Key Laboratory of Quality Markers of Traditional Chinese Medicine, Tianjin 300462, China
National Key Laboratory of Drug Druggability Evaluation and Systematic Transformation, Tianjin 300462, China | tiancw@tipr.com.cn | | ZHANG Caixia | Tianjin Institute of Materia Medica, Heguang Chinese Medicine Technology(Tianjin) Co., Ltd., Tianjin 300462, China
Tianjin Key Laboratory of Quality Markers of Traditional Chinese Medicine, Tianjin 300462, China
National Key Laboratory of Drug Druggability Evaluation and Systematic Transformation, Tianjin 300462, China | zhangcx@tipr.com.cn |
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| Abstract
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| Type 2 diabetes mellitus（T2DM） is a complex metabolic disorder with complex pathogenesis，which is prone to cause a variety of complications and seriously threatens human health. While traditional therapeutic drugs play a hypoglycemic role，most of them will produce serious side effects and induce diabetic complications，while some alkaloids with hypoglycemic effects have attracted people’s attention because of their advantages of wide range of sources and low toxic side effects. At present，a large number of literature has reported that alkaloids have good hypoglycemic activity and can actively treat diabetic complications. In this paper，we summarize the representative alkaloid monomer components，such as berberine，1-deoxynojirimycin，dendrobine，matrine，etc.，and review the pharmacological mechanism of their pharmacological effects in the treatment of type 2 diabetes mellitus and its complications. In order to provide a theoretical reference for the treatment of type 2 diabetes and its complications and the development of alkaloid drugs. |
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