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| The Role of the Notch Signaling Pathway in Cardiovascular Diseases and the Regulatory Mechanisms of Traditional Chinese Medicine |
| Hits 429 Download times 259 Received:January 10, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2025.06.10 |
| Key Words
Notch signaling pathway;myocardial infarct;atherosclerosis;signal regulation |
| Author Name | Affiliation | E-mail | | WANG Jilu | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
School of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Rui | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | JIA Fuyun | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | Bonsu Opoku Francis | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Ruiqiao | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Components of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LENG Ling | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Components of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Shaoxia | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
School of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | wangshaoxia1@163.com | | WANG Qilong | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Components of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | wangqilong_00@tjutcm.edu.cn |
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| Abstract
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| The Notch signaling pathway, is a highly conserved and essential mechanism in regulating cell growth, differentiation, development, tissue repair, and organ formation. Its function has been intrinsically linked to the development, growth, and homeostasis of the heart. Nonetheless, several research has shown that dysfunction of the Notch pathway is implicated in the development and progression of some cardiovascular diseases. Traditional Chinese medicine(TCM) has shown promise in treating cardiovascular diseases by regulating factors involved in the pathways that underscore the pathogenesis of the disease. This article summarizes the relationship between the Notch signaling pathway and various cardiovascular diseases while highlighting the regulatory effects of traditional Chinese medicine on the Notch signaling in treating these conditions. By carefully outlining these interactions, we seek to present a concise mechanism of action of traditional Chinese medicine in preventing and treating cardiovascular diseases. |
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