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| Research progress on the influence of traditional Chinese medicine on gut microbiota metabolites on colorectal cancer |
| Hits 457 Download times 252 Received:February 16, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2025.06.11 |
| Key Words
colorectal cancer;traditional Chinese medicine;gut microbiota;gut microbiota metabolites;molecular mechanism |
| Author Name | Affiliation | E-mail | | YANG Meng | Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Department of Clinical Laboratory, Tianjin People's Hospital, Tianjin 300122, China | | | PANG Wenwen | Department of Clinical Laboratory, Tianjin People's Hospital, Tianjin 300122, China | | | ZHANG Shuai | School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Weihua | Department of General Surgery, Tianjin Haihe Hospital, Tianjin 300350, China | tjs_zwh@126.com |
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| Abstract
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| Colorectal cancer(CRC), a prevalent malignancy of the digestive system, has garnered significant attention in recent years. Emerging evidence highlights the critical role of gut microbiota homeostasis in maintaining health, with dysbiosis closely linked to diseases such as CRC. Metabolites derived from gut microbiota, including short-chain fatty acids, bile acids, and indole derivatives, regulate the intestinal microenvironment, modulate inflammation, and influence apoptosis, playing pivotal roles in CRC onset and progression. Traditional Chinese medicine(TCM) has become a focal point of CRC research due to its potential to regulate gut microbiota and their metabolites, demonstrating promise in prevention and therapy. Future studies should elucidate the underlying mechanisms of TCM to provide a scientific basis for developing effective CRC management strategies. |
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