|
| Research progress on traditional Chinese medicine in preventing and treating 5-fluorouracil-induced immunosuppression |
| Hits 300 Download times 113 Received:August 02, 2025 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1673-9043.2025.12.11 |
| Key Words
malignant tumors;5-fluorouracil;chemotherapy;immunosuppression;mechanism of action;traditional Chinese medicine;cytokines |
| Author Name | Affiliation | E-mail | | SHEN Ru | State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | QI Yubo | State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Yue | State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Taigui | State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | FENG Yuxin | State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | fengyn2016@163.com |
|
| Abstract
|
| Malignant tumors pose a serious threat to people’s life and health. Chemotherapy is one of the commonly used methods for treating malignant tumors in clinical practice. Immunosuppression is the most common toxic side effect during chemotherapy，which can increase the risk of infection and affect the prognosis of cancer patients. 5-FU can induce immunosuppression as an adverse reaction，seriously threatening patient survival. Therefore，understanding the mechanism of 5-FU-induced immunosuppression is crucial for effectively guiding clinical medication and developing new drugs to mitigate this side effect，thereby improving patient survival and prognosis. Currently，Traditional Chinese Medicine（TCM） plays a positive role in ameliorating chemotherapy-induced immunosuppression and can significantly enhance patients’ immunity. This review will focus on both the mechanism of 5-FU-induced immunosuppression and the research progress in TCM for preventing and treating 5-FU-induced immunosuppression， aiming to provide a solid theoretical basis for TCM in managing chemotherapy-induced immunosuppression. |
|
|
|
|
|
