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| Research progress on PINK1/Parkin pathway-mediated mitophagy in the prevention and treatment of Parkinson’s disease with integrated Chinese and Western medicine |
| Hits 230 Download times 187 Received:September 10, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2026.01.15 |
| Key Words
integrated Chinese and Western medicine;Parkinson’s disease;PINK1;Parkin;mechanism of action;research progress |
| Author Name | Affiliation | E-mail | | LIU Xin | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | | | LI Wei | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | | | DU Yuzheng | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | drduyuzheng@126.com | | ZHANG Lili | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | | | WANG Bing | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | | | CAO Rui | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | | | ZHENG Gaohan | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine, Tianjin 300381, China | |
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| Abstract
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| Parkinson’s disease（PD） is a common neurodegenerative disorder with a complex pathogenesis. Current clinical treatments have limited efficacy，making it difficult to effectively control disease progression. Mitochondrial dysfunction is a key factor leading to neuronal damage，and the imbalance of mitochondrial homeostasis is a crucial link in triggering mitochondrial dysfunction. The occurrence and development of PD are often accompanied by the disruption of mitochondrial homeostasis in neurons. Mitophagy，as a core mechanism regulating mitochondrial homeostasis，is of great significance for the prevention and treatment of PD. The PTEN-induced putative kinase 1（PINK1）/Parkin pathway is one of the classical pathways regulating mitophagy. Currently，studies have found that certain drugs and acupuncture treatments for PD can exert neuroprotective effects by modulating the PINK1/Parkin signaling pathway to target and improve neuronal mitochondrial homeostasis. In particular，the intervention of traditional Chinese medicine in regulating PINK1/Parkin pathway-mediated mitophagy for PD has attracted much attention. The article reviews the impact of PINK1/Parkin-mediated mitophagy on PD from the perspective of the PINK1/Parkin pathway and explores the therapeutic effects of both Chinese and Western medicine on PD by regulating this pathway，aiming to provide new research insights for the prevention and treatment of PD with integrated Chinese and Western medicine. |
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