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| Research progress on traditional Chinese medicine regulating AMPK signaling pathway for coronary heart disease |
| Hits 168 Download times 32 Received:August 22, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2026.01.16 |
| Key Words
coronary atherosclerotic heart disease;AMP-activated protein kinase;atherosclerosis;traditional Chinese medicine regulation |
| Author Name | Affiliation | E-mail | | LYU Xinliang | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YAN Jingshun | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Wenyue | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHAO Mei | Department of Cardiology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | ZHANG Hongxia | Department of Cardiology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | ywzlp@163.com | | ZHU Linping | Department of Cardiology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | zhulinping@tjutcm.edu.cn |
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| Abstract
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| The incidence of coronary atherosclerotic heart disease（CHD） is showing a trend toward affecting younger individuals and has become one of the diseases with the highest mortality rates in China. Current research indicates that AMP-activated protein kinase（AMPK） participates in the entire process of CHD occurrence and development by influencing biological processes such as cardiomyocyte injury，death，proliferation，and transformation. In recent years，studies on traditional Chinese medicine（TCM） in cardiovascular diseases have demonstrated its favorable clinical efficacy and minimal adverse reactions. Concurrently，numerous experimental studies have been conducted on TCM regulating the AMPK signaling pathway for CHD treatment. The article reviews and summarizes recent relevant literature，outlines the role of AMPK in the pathogenesis of CHD，and summarizes progress of in vivo and in vitro experimental research on TCM regulation of AMPK and its related signaling pathways，aiming to provide insights for a deeper understanding of CHD pathogenesis and TCM treatment strategies. |
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