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| Exploring the impact of gut microbiota on hypertension risk and the theory of traditional Chinese medicine intervention |
| Hits 172 Download times 45 Received:November 28, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2026.02.04 |
| Key Words
Mendelian Randomization;gut microbiota;hypertension;traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | GUO Junchi | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Department of Cardiology, Tianjin 300250, China
Tianjin University of Traditional Chinese Medicine, Graduate School, Tianjin 301617, China | | | YANG Peili | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Department of Cardiology, Tianjin 300250, China
Tianjin University of Traditional Chinese Medicine, Graduate School, Tianjin 301617, China | | | ZHANG Mingyan | Tianjin University of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHAO Yingqiang | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Department of Cardiology, Tianjin 300250, China | | | LU Meijuan | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Department of Cardiology, Tianjin 300250, China | lmj830127@163.com |
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| Abstract
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| [Objective] This study aims to explore the causal relationship between gut microbiota and hypertension using Mendelian Randomization（MR）methods，and to further analyze the role of specific microbiota in hypertension risk. [Methods] The study employed three Mendelian Randomization analysis methods：Inverse-Variance Weighted （IVW），MR-Egger，and Weighted Median，using two-sample data to evaluate the impact of different gut microbiota on hypertension risk. The data used in this study were obtained from publicly available Genome-Wide Association Study（GWAS）databases，with gut microbiota as the exposure factor and hypertension as the outcome variable. [Results] The MR results indicated that certain gut microbiota，such as Actinobacteria，Desulfovibrionaceae，and Geobacteraceae，were significantly positively associated with an increased risk of hypertension，while microbiota such as Acetobacteraceae and Dokdonella were associated with a reduced risk of hypertension. The consistency of results across multiple analysis methods strengthens the robustness of the findings. [Conclusion] This study confirmed，through MR analysis，a causal relationship between specific gut microbiota and hypertension，providing new insights for hypertension prevention and intervention. Additionally，the overall regulatory effects of Traditional Chinese Medicine（TCM） in restoring gut microbiota balance and hypertension management hold significant potential，warranting further research and application. |
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