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| Study on the stability of Shuganning Injection with other three clinical-used injections |
| Hits 120 Download times 34 Received:November 15, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2026.02.08 |
| Key Words
Shuganning injection;glutathione for injection;magnesium isoglycyrrhizinate injection;polyene phosphatidylcholine injection;compatibility stability |
| Author Name | Affiliation | E-mail | | ZHANG Linhui | State Key Laboratory for Component-based Chinese Medicines, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Ministry of Education Engineering & Research Center for Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SHEN Pengyu | State Key Laboratory for Component-based Chinese Medicines, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Ministry of Education Engineering & Research Center for Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | HUANG Xiaochao | State Key Laboratory for Component-based Chinese Medicines, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Ministry of Education Engineering & Research Center for Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | HOU Xiaotong | State Key Laboratory for Component-based Chinese Medicines, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Ministry of Education Engineering & Research Center for Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | HU Yiwen | State Key Laboratory for Component-based Chinese Medicines, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Ministry of Education Engineering & Research Center for Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | JIAN Ruihong | State Key Laboratory for Component-based Chinese Medicines, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Ministry of Education Engineering & Research Center for Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YANG Cuiping | Guizhou Ruihe Pharmaceutical Co. Ltd., Qiannan 551200, China | | | HE Feng | School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China | 838396231@qq.com | | PI Jiaxin | State Key Laboratory for Component-based Chinese Medicines, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Ministry of Education Engineering & Research Center for Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | pijiaxin@tjutcm.edu.cn |
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| Abstract
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| [Objective] To investigate the stability of Shuganning Injection（SGN）after it was compatible with three commonly clinical-used injections（Glutathione for Injection，Magnesium Isoglycyrrhizinate Injection and Polyene Phosphatidylcholine Injection）. [Methods] SGN and the above injections were prepared separately according to the instructions for use，and then mixed. After mixing，the pH，insoluble particles，and ingredients（chlorogenic acid， gardenin，baicalin and adenosine）of SGN were investigated at different time points. [Results] There was no significant change in the properties of the finished solution of Shuganning injection；the pH value decreased slightly， and the sub-visible particles did not exceed the limit within 8 h，which was in line with the provisions of the pharmacopoeia. The contents of the four components chlorogenic acid，gardenin，baicalin and adenosine did not change much. [Conclusion] Shuganning Injection can be used in combination with Glutathione for Injection， Magnesium Isoglycyrrhizinate Injection and Polyene Phosphatidylcholine Injection. |
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