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| Role of m6A modification in atherosclerosis and the research progress of traditional Chinese medicine intervention |
| Hits 223 Download times 32 Received:November 24, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2026.02.13 |
| Key Words
m6A methylation;atherosclerosis;Chinese medicine;mechanism of action |
| Author Name | Affiliation | E-mail | | DU Zichen | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Third Department of Cardiology, Tianjin People's Hospital, The First Affiliated Hospital of Nankai University, Tianjin 300121, China | | | WU Mengyuan | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Jiao | Third Department of Cardiology, Tianjin People's Hospital, The First Affiliated Hospital of Nankai University, Tianjin 300121, China | | | WEI Liping | Third Department of Cardiology, Tianjin People's Hospital, The First Affiliated Hospital of Nankai University, Tianjin 300121, China | weilipingme@163.com |
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| Abstract
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| The high prevalence of cardiovascular diseases（CVDs）is still the most important health concern of the people，which seriously affects the quality of life of patients. Atherosclerosis is one of the underlying pathological factors of cardiovascular diseases. N6-methyladenosine（m6A）methylation modification，as the most common epigenetic modification of RNA in eukaryotic cells，has been found to play a key role in the development of atherosclerosis in recent years. Studies have shown that m6A can participate in the pathological progression of atherosclerosis by regulating inflammatory responses，lipid metabolism disorders and other processes. Traditional Chinese medicine（TCM）has demonstrated the advantage of multi-target regulation in the prevention and treatment of atherosclerosis（AS），and some of the active ingredients and compound preparations of TCM can intervene in AS- related signaling pathways by regulating the expression of m6A-related enzymes or RNA modification levels. However，the study of m6A intervention by TCM is still in the initial stage，and the mechanism of action and the material basis of pharmacological effect need to be analyzed in depth by combining various techniques. In the future，it is necessary to integrate the theories of epigenetics and traditional Chinese medicine to promote the development of precise therapeutic strategies for AS. |
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