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| Effects of walnut kernel on the pharmacokinetics of psoralea corylifolia in rats |
| Hits 155 Download times 19 Received:November 10, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2026.03.06 |
| Key Words
psoralea corylifolia;walnut kernel;pharmacokinetics;UHPLC-MS/MS |
| Author Name | Affiliation | E-mail | | WANG Aixi | Center of Drug Safety Evaluation, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CAO Jinghao | Center of Drug Safety Evaluation, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | GAO Li | Center of Drug Safety Evaluation, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Jinyu | Center of Drug Safety Evaluation, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Yue | Center of Drug Safety Evaluation, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHOU Kun | Center of Drug Safety Evaluation, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | z.k.ken@263.net |
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| Abstract
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| [Objective] This experiment aimed to investigate the effect of walnut kernel on the pharmacokinetics of Psoralea corylifolia extract in rats. [Methods] Twelve male SD rats were divided into two groups（n=6 per group）：the Psoralea corylifolia group（receiving Psoralea corylifolia extract at 1.05 g/kg） and the co-administration group （receiving Psoralea corylifolia extract at 1.05 g/kg plus walnut kernel at 0.66 g/kg）. Approximately 300 μL of blood was collected from the orbital venous plexus before administration（0 h） and at 12 time points post-administration. The upper plasma layer was collected and analyzed using the established method. [Results] The pharmacokinetic parameters showed that the most of the compatible rats had decreased AUC and Cmax levels, including isopsoralen, bavachinin, isobavachalcone, neobavaisoflavone and bakuchalcone. [Conclusion] This study indicates that walnut kernel can reduce the systemic exposure levels and shorten the retention time of most active components of Psoralea corylifolia in rats, thereby altering its pharmacokinetic profile. This finding provides a pharmacokinetic perspective on the potential mechanism by which walnut kernel alleviates Psoralea corylifolia-induced hepatotoxicity. |
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