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| Effects of Danggui Sini Decoction on Neurotoxicity Response and Karnofsky Performance Status Score in Patients with Chemotherapy-Induced Neurotoxicity |
| Hits 179 Download times 37 Received:January 26, 2026 |
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| DOI
10.11656/j.issn.1673-9043.2026.05.05 |
| Key Words
Danggui Sini Decoction;chemotherapy;neurotoxicity;karnofsky;nerve conduction velocity |
| Author Name | Affiliation | E-mail | | SHEN Zhenyan | Department of Radiotherapy and Chemotherapy, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou 061001, China | | | ZHANG Cheng | Department of Hepatobiliary and Pancreatic Surgery, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou 061001, China | | | HU Xiuru | Department of Radiotherapy and Chemotherapy, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou 061001, China | 15833179892@139.com | | HE Xinying | Department of Radiotherapy and Chemotherapy, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou 061001, China | | | LIU Yue | Department of Radiotherapy and Chemotherapy, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou 061001, China | | | YANG Hongjuan | Department of Radiotherapy and Chemotherapy, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou 061001, China | | | XIAO Li | Department of Radiotherapy and Chemotherapy, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou 061001, China | | | YANG Wenbo | Department of Radiotherapy and Chemotherapy, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou 061001, China | |
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| Abstract
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| [Objective] To explore the effects of Danggui Sini Decoction on neurotoxicity response and Karnofsky Performance Status（KPS）score in patients with chemotherapy-induced neurotoxicity（CIPN）. [Methods] From October 2021 to October 2023，88 patients who underwent chemotherapy and developed neurotoxicity in our hospital were randomly divided into Western medicine group（1 case dropped out，n=43，treated with methylcobalamin）and Chinese-Western medicine group（2 cases dropped out，n=42，treated with Danggui Sini Decoction in addition to the Western medicine group）using a random number table method. The changes in National Cancer Institute Common Terminology Criteria for Adverse Events（NCI-CTCAE）grading，nerve conduction velocity（including motor nerve conduction velocity（MNCV）and sensory nerve conduction velocity（SNCV）），serum nerve growth factor（NGF） level，KPS score，adverse reactions and quality of life were compared between the two groups before and after 4 weeks of treatment. [Results] After 4 weeks of treatment，the NCI-CTCAE grading of both groups was better than before treatment（P<0.05），and the NCI-CTCAE grading of the Chinese-Western medicine group was better than that of the Western medicine group（P<0.05）；the MNCV and SNCV of the median nerve and common peroneal nerve in both groups were faster than those before treatment（P<0.05），and the nerve conduction velocity in the Chinese-Western medicine group was faster than that in the Western medicine group（P<0.05）；the serum NGF level，KPS score，physical function，emotional function and social function scores of both groups were higher than before treatment（P<0.05），and the Chinese-Western medicine group was higher than the Western medicine group （P<0.05）. There was no difference in the total incidence of adverse reactions between the Chinese-Western medicine group and the Western medicine group（11.90% vs. 6.98%，P>0.05）. [Conclusion] The application of Danggui Sini Decoction has a better therapeutic effect on CIPN patients，which can effectively upregulate serum NGF level，obviously improve nerve conduction velocity and condition，and significantly enhance health level and quality of life. |
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