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| Multidimensional regulatory mechanisms of traditional Chinese medicine in stem cell modulation for antidepressant efficacy：research progress |
| Hits 176 Download times 36 Received:December 20, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2026.05.14 |
| Key Words
depression;stem cells;traditional Chinese medicine;nerve regeneration;neurotransmitters;neuroinflammation |
| Author Name | Affiliation | E-mail | | LIN Yang | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SHI Yuexuan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Jida | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Ying | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WU Yue | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Mengqi | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | FAN Zezhi | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Xingping | Weifang People's Hospital, Weifang 261000, China
Shandong Second Medical University, Weifang 261000, China | | | BIAN Yuhong | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | bianyuhong_2012@163.com |
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| Abstract
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| Depression，a globally prevalent mental disorder，involves multifaceted pathological mechanisms such as neuroinflammation，imbalance of monoamine neurotransmitters，abnormal synaptic plasticity，and dysfunction of the hypothalamic-pituitary-adrenal axis. Conventional antidepressants face limitations，including unstable efficacy， drug dependence，and osteogenic suppression，necessitating the exploration of novel therapeutic strategies. In recent years，stem cells have demonstrated unique potential in depression treatment due to their properties of self-renewal， multipotent differentiation，and homing effects. This article systematically reviews the core mechanisms by which stem cells exert antidepressant effects through neuronal regeneration， neurotransmitter balance， and immunomodulation. Additionally，it explores the feasibility of Traditional Chinese Medicine（TCM）in modulating stem cell functions to alleviate depressive symptoms，aiming to provide innovative insights and theoretical foundations for depression treatment. |
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