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| Research progress of traditional Chinese medicine intervention in myocardial ischemia-reperfusion injury based on TLR4 signaling pathway |
| Hits 176 Download times 38 Received:November 30, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2026.05.15 |
| Key Words
traditional Chinese medicine;myocardial ischemia reperfusion injury;Toll-like receptor 4（TLR4） signaling pathway;mechanism;research progress |
| Author Name | Affiliation | E-mail | | LIU Yiman | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | JIA Huiyu | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | GUO Liuli | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | FENG Wenshuai | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Bin | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | JIANG Feng | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | wecm@sina.com | | REN Ming | Baokang Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin 300073, China | renming2008@126.com |
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| Abstract
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| Myocardial ischemia-reperfusion injury（MIRI）is one of the complications of reperfusion therapy，and its pathological mechanism involves a complex cascade of multifactorial involvement. Among them，the innate immune response mediated by Toll-like receptor 4（TLR4）plays a key role in the MIRI process by regulating pathological processes such as the inflammatory cascade，and its activation may lead to the intensification of inflammatory response and aggravation of myocardial injury. Traditional Chinese medicine（TCM）has the unique advantages of multiple pathways，multiple effects，and multiple targets. A large number of studies have shown that TCM can effectively intervene in the progression of MIRI by regulating the TLR4 signaling pathway，inhibiting inflammatory responses，and protecting cardiomyocytes. Therefore，this article summarizes the structure and function of TLR4，the mechanism of action of the TLR4 signaling pathway in MIRI，and summarizes the research progress of traditional Chinese medicine in regulating the TLR4 signaling pathway in the treatment of MIRI，in order to provide a theoretical basis and translational direction for the basic research and clinical development of new drugs in MIRI. |
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