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| Clinical study of Buyang Huanwu Decoction combined with conventional western medicine in the treatment of acute cerebral infarction of qi deficiency and blood stasis type |
| Hits 100 Download times 47 Received:December 28, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2026.06.05 |
| Key Words
acute cerebral infarction;Buyang Huanwu Decoction;national institutes of health stroke scale;homocysteine;matrix metalloproteinase-9 |
| Author Name | Affiliation | E-mail | | WANG Yakuan | Department 2 of Brain Disease, Henan Integrated Traditional Chinese and Western Medicine Hospital, Zhengzhou 450000, China | | | ZHAO Jinwei | Department 2 of Brain Disease, Henan Integrated Traditional Chinese and Western Medicine Hospital, Zhengzhou 450000, China | | | CHEN Qiuyun | Department 2 of Brain Disease, Henan Integrated Traditional Chinese and Western Medicine Hospital, Zhengzhou 450000, China | | | LIU Zhongjie | Department 2 of Brain Disease, Henan Integrated Traditional Chinese and Western Medicine Hospital, Zhengzhou 450000, China | | | LIU Zhongyi | Department 2 of Brain Disease, Henan Integrated Traditional Chinese and Western Medicine Hospital, Zhengzhou 450000, China | | | LIU Jieqiong | Department 2 of Brain Disease, Henan Integrated Traditional Chinese and Western Medicine Hospital, Zhengzhou 450000, China | | | WANG Ming | Scientific Research and Teaching Department, Henan Integrated Traditinal Chinese and Western Medicine Hospital, Zhengzhou 450000, China | wmtcm@qq.com |
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| Abstract
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| [Objective] To investigate the efficacy of the Buyang Huanwu decoction combined with conventional Western medicine in treating qi deficiency and blood stasis type acute cerebral infarction（ACI），as well as its effects on neurological function，homocysteine（Hcy），and matrix metalloproteinase-9（MMP-9）. [Methods] A randomized controlled trial design was adopted. From October 2023 to August 2025，184 patients with qi deficiency and blood stasis type ACI were selected and randomly divided into the control group and the observation group at a ratio of 1∶1 using a computer-generated random number sequence，with 92 cases in each group. The control group received conventional western medical treatment（controlling blood pressure and blood sugar，lipid regulation，antiplatelet therapy，improving circulation，and nourishing the nervous system，etc.），while the observation group was treated with the Buyang Huanwu decoction in addition to the treatment of the control group，one dose per day，for a course of 4 weeks. The NIHSS scores，TCM syndrome scores，clinical efficacy，and serum levels of Hcy，MMP-9，neuron-specific enolase（NSE），superoxide dismutase（SOD），and malondialdehyde（MDA） before and after treatment were compared between the two groups. [Results] After treatment，the NIHSS scores，TCM syndrome scores，and serum levels of Hcy，MMP-9，NSE，and MDA in both groups were significantly lower than those before treatment（P<0.05），and the SOD level was significantly higher（P<0.05）. The improvement in the observation group was significantly better than that in the control group（P<0.05）. The total clinical effective rate of the observation group was 98.91%，significantly higher than that of the control group（82.61%）（P<0.05）. There was no significant difference in the incidence of adverse reactions between the two groups. [Conclusion] The combination of Buyang Huanwu decoction with conventional western medical treatment can significantly improve the neurological function，TCM syndrome，and serum indicators of patients with qi deficiency and blood stasis type ACI. It is safe and its effect may be through multi-target intervention to interfere with multiple key pathological links of ACI. |
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