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| Inflammation-angiogenesis crosstalk as a novel target for diabetic macrovascular complications： Clinical evidence，mechanism insights，and the potential of traditonal Chinese medicine in prevention and treatment |
| Hits 74 Download times 52 Received:January 25, 2026 |
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| DOI
10.11656/j.issn.1673-9043.2026.06.14 |
| Key Words
diabetic macrovascular complications;inflammation-angiogenesis crosstalk;traditional Chinese medicine compound prescriptions;monomeric components of traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | LI Siyu | State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | FAN Siwen | State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Junyi | State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHU Yan | State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | yanzhu.harvard@icloud.com | | HE Shuang | State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | heshuang@tjutcm.edu.cn |
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| Abstract
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| Diabetic macrovascular complications are characterized by atherosclerosisas a core feature. Hyperglycemia leads to endothelial dysfunction，imbalanced angiogenesis，and plaque instability through mechanisms such as oxidative stress，accumulation of advanced glycosylation end products，and chronic inflammation，thereby contributing to coronary artery disease，cerebrovascular disease，and peripheral arterial disease. The complex pathophysiological progression and underlying pathogenic mechanisms of these complications have hindered significant breakthroughs in new drug development. Recent studies suggest that inflammation-angiogenesis crosstalk（IAC） may serve as a “common soil” for diabetic vascular complications，and targeting IAC holds promise for overcoming current therapeutic limitations. This article systematically reviews the pathogenesis of diabetic macrovascular complications and explored the role and clinical significance of IAC. Traditional Chinese Medicine（TCM） exhibits unique advantages in this field by leveraging multi-target regulation to simultaneously suppress inflammation and promote functional angiogenesis. This review provides an in-depth analysis of the inflammation-angiogenesis crosstalk mechanism and the multi-pathway intervention strategies of TCM，offering novel insights into the prevention and treatment of diabetic macrovascular complications. Future research should further validate the regulatory of key targets and promote the clinical translation of integrated traditional Chinese and Western medicine approaches. |
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