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| Advances in hyaluronic acid-functionalized nano-delivery system for improving oral bioavailability of active ingredients in traditional Chinese medicine |
| Hits 70 Download times 47 Received:February 16, 2026 |
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| DOI
10.11656/j.issn.1673-9043.2026.06.16 |
| Key Words
active ingredients of traditional Chinese medicine;hyaluronic acid and its derivatives;oral bioavailability;drug delivery system |
| Author Name | Affiliation | E-mail | | ZHANG Yunxin | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHI Hui | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SUN Yujiao | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | sunyujiao@tjutcm.edu.cn | | LI Yingpeng | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | liyingpeng@tjutcm.edu.cn |
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| Abstract
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| For the delivery of traditional Chinese medicine（TCM） active ingredients that are poorly soluble，easily metabolized，and difficult to cross biological barriers，hyaluronic acid-functionalized nanocarrier systems demonstrate multiple advantages，primarily due to their excellent biocompatibility and biodegradability. These carriers effectively enhance the solubility of TCM active ingredients，maintain drug stability，and promote intestinal absorption，thereby significantly improving the bioavailability of oral administration. This review summarizes the current published research findings on hyaluronic acid-functionalized nanocarrier systems as oral drug delivery carriers for delivering active components of TCM. The aim is to provide new strategies for improving the oral bioavailability of active components of TCM and to offer new avenues for advancing the modernization of TCM. |
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