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| Comparative study on the loading performance of borneol by β-cyclodextrin and silica gel |
| Hits 193 Download times 77 Received:June 06, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2025.10.05 |
| Key Words
borneol;β-cyclodextrin;silica gel;loading capacity;performance comparison |
| Author Name | Affiliation | E-mail | | LIN Yun | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | DENG Xiuping | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Yanling | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | XIE Haonan | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | JIAO Guorui | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Zhidong | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | lonerliuzd@163.com | | WANG Jia | Tianjin Tongrentang Group Co. Ltd., Tianjin 300385, China | tjtrt_jszx@163.com |
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| Abstract
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| [Objective] The study aimed to compare the loading capacity and efficiency of borneol using β-cyclodextrin(β-CD,a common pharmaceutical excipient) and silica gel SYLOID 244FP,to provide more options for the application of borneol in traditional Chinese medicine preparations. [Methods] The β-CD-borneol inclusion complex was prepared using the saturated aqueous solution method,while the SYLOID 244FP-borneol complex was prepared by direct mixing. Phase characterization was performed using Fourier transform infrared spectroscopy(FT-IR) and differential scanning calorimetry(DSC). The content was determined by gas chromatography(GC),and the in vitro dissolution rate was investigated. The stability of the two complexes was compared using an accelerated stability test. [Results] The average borneol content in the β-CD inclusion complex was 11.57%,whereas that in the SYLOID 244FP complex was 46.32%. Regarding the in vitro dissolution rate,the SYLOID 244FP-borneol complex demonstrated the fastest release,followed by the β-CD-borneol inclusion complex,and finally pure borneol. After 14 days of accelerated testing at 40℃ and 75% relative humidity,the relative content of borneol decreased to 0%(pure borneol),92.88%(β-CD-borneol inclusion complex),and 1.91%(SYLOID 244FP-borneol complex),respectively. [Conclusion] Both β-CD and SYLOID 244FP can effectively load borneol. However,β-CD demonstrated superior performance in enhancing the stability of borneol,while SYLOID 244FP exhibited a higher loading capacity and faster in vitro dissolution rate. The study provides valuable insights for selecting appropriate excipients for borneol in traditional Chinese medicine preparations. |
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