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| Systematic review of effectiveness and safety of traditional Chinese medicine for COVID-19 based on core outcome set |
| Hits 298 Download times 95 Received:July 02, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2025.10.07 |
| Key Words
COVID-19;traditional Chinese medicine;systematic review;methodology;clinical efficacy |
| Author Name | Affiliation | E-mail | | SHENG Xiaodi | Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China | | | JI Zhaochen | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CHEN Chao | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | | | ZHANG Dong | Center for Evidence-Based Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CHU Mingyan | Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China | | | HU Haiyin | Haihe Laboratory of Modern Traditional Chinese Medicine, Tianjin 301617, China | | | TAN Kexuan | Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China | | | GUO Liping | Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China | lpgtjn@163.com |
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| Abstract
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| [Objective] To systematically evaluate the effectiveness and safety of traditional Chinese medicine(TCM) across core outcome indicators for COVID-19. [Methods] Systematically searched CNKI,SinoMed,WanFang Database,VIP,PubMed,Embase,the Cochrane Library,and Web of Science for randomized controlled trials(RCT) on TCM for COVID-19. Two reviewers independently screened studies,extracted data,and assessed methodological quality. Data analysis was performed using R software. [Results] Thirty-three RCTs involving 6 349 patients and 23 TCM formulations were included,all with some risk of bias. Regarding time to nucleic acid conversion:Shufeng Jiedu Capsule,Gegen Qinlian Pill,and Xuanfei Baidu Formula shortened this time in mild patients;Jinyinhua Oral Liquid,Shufeng Jiedu Capsule,and Xuanfei Baidu Formula did so in moderate patients;and Gegen Qinlian Pill shortened it in severe patients. For hospital stay:Jinyinhua Oral Liquid,Tanreqing Injection,and Qingfei Paidu Decoction reduced hospital stay for moderate patients,while Xuebijing Injection,Tanreqing Injection,and Qingfei Paidu Decoction did so for severe patients. For progression to severe/critical rate:Jinyinhua Oral Liquid and Lianhua Qingwen Capsule reduced progression in moderate patients,and Xuebijing Injection reduced progression to critical condition in severe patients. For clinical symptom scores:Liushen Capsule and Qingfei Paidu Decoction improved scores in moderate patients. For mortality:Xuebijing Injection reduced mortality in severe patients,and Shenhuang Granule reduced mortality in severe and critical patients. [Conclusion] TCM combined with conventional Western medicine demonstrates favorable efficacy for COVID-19 with a lower incidence of adverse reactions. However,due to limitations of the included studies,these findings require further validation by more high-quality research. |
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