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| Systematic review on efficacy and safety of treating gout based on the theory of “managing toxin pathogenesis” |
| Hits 229 Download times 83 Received:May 12, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2025.10.08 |
| Key Words
traditional Chinese medicine;managing toxin pathogenesis;clearing dampness，promoting blood circulation and detoxifying;gout;Meta-analysis |
| Author Name | Affiliation | E-mail | | LI Suiran | Department of Rheumatology and Immunology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Wei | Department of Rheumatology and Immunology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | fengshiliuwei@163.com | | WANG Yiwen | Department of Rheumatology and Immunology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Jiamin | Department of Rheumatology and Immunology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | TANG Zhuo | Department of Rheumatology and Immunology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Wen | Department of Rheumatology and Immunology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | |
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| Abstract
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| [Objective] To systematically evaluate the clinical efficacy and safety of traditional Chinese medicine(TCM) interventions for gout based on the "clearing dampness,promoting blood circulation,and detoxifying" method from the perspective of toxin pathogenesis. [Methods] Randomized controlled trials(RCTs) meeting the inclusion criteria were systematically retrieved from Chinese and English databases(CNKI,Wanfang,VIP,and PubMed) from their inception to December 1,2024. The Cochrane Risk of Bias Tool 2.0(RoB 2.0) was used to assess literature quality,RevMan 5.4 was employed for Meta-analysis,and the GRADE system was applied to evaluate the quality of evidence. [Results] Ten studies involving 960 patients were included. Compared with Western medicine treatment alone,TCM interventions based on the "managing toxin pathogenesis" theory demonstrated superior outcomes in multiple indicators:improved clinical response rate[RR=1.20,95%CI(1.13,1.27),P<0.000 01];reduced TCM syndrome score[SMD=-1.55,95%CI(-1.87,-1.22),P<0.000 01];decreased joint pain score[SMD=-1.05, 95%CI(-1.21,-0.89),P<0.000 01];reduced joint mobility limitation score[SMD=-0.95,95%CI(-1.17,-0.72),P<0.000 01];decreased serum uric acid[MD=-48.73,95%CI(-55.63,-41.83),P<0.000 01];reduced erythrocyte sedimentation rate[MD=-4.75,95%CI(-5.28,-4.22),P<0.000 01];lowered C-reactive protein[MD=-6.24,95%CI(-6.73,-5.75),P<0.000 01];decreased tumor necrosis factor-α[MD=-7.22,95%CI(-8.48,-5.96),P<0.000 01];and reduced interleukin-6[MD=-4.45,95%CI(-5.31,-3.59),P<0.000 01]. Furthermore,the incidence of adverse reactions was significantly lower[RR=0.59,95%CI(0.35,0.99),P=0.05]. [Conclusion] Integrated treatment with TCM based on the "managing toxin pathogenesis" theory combined with Western medicine can significantly improve clinical efficacy and exhibit better safety in treating gout. |
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