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| The effect of Maiguan Fukang capsule on neurological function in patients with ischemic stroke sequelae by regulating endoplasmic reticulum stress- autophagy |
| Hits 182 Download times 65 Received:May 03, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2025.11.02 |
| Key Words
Maiguan Fukang Capsules;ischemic stroke sequelae;endoplasmic reticulum stress;autophagy;neurological function |
| Author Name | Affiliation | | ZHAO Haichuan | Intravenous Drug Configuration Center, Xingtai Central Hospital, Xingtai 054000, China | | SHI Zhina | Intravenous Drug Configuration Center, Xingtai Central Hospital, Xingtai 054000, China | | TIAN Yu | CCU, Xingtai Central Hospital, Xingtai 054000, China | | LI Zhiwen | Department of Neurology, Xingtai Central Hospital, Xingtai 054000, China |
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| Abstract
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| [Objective] To investigate the promoting effect of Maiguan Fukang capsule on neurological recovery and its regulatory effect on endoplasmic reticulum stress-autophagy in patients with ischemic stroke sequelae.[Methods] From February 2019 to February 2023,124 patients with ischemic stroke sequelae admitted to our hospital were randomly divided into an observation group and a control group,with 62 cases in each group. The control group received basic treatment,while the observation group received basic treatment combined with oral administration of Maiguan Fukang capsules. After 8 weeks of treatment,neurological function,traditional Chinese medicine syndrome score,clinical efficacy,hemorheological indicators,inflammatory factors,and the mRNA and protein expression of endoplasmic reticulum stress-autophagy related genes were evaluated.[Results] After treatment,the NIHSS score of the observation group was significantly lower than that of the control group,while the Fugl-Meyer score and BI index were significantly higher(P<0.05). The TCM syndrome score and total effective rate were significantly higher than those of the control group(P<0.05). After treatment,the whole blood viscosity,fibrinogen,and peripheral cerebrovascular resistance in the observation group were significantly lower,while the mean blood flow velocity in the middle and basilar arteries was significantly higher(P<0.05). The levels of IL-6,hs-CRP,and TNF-α in the observation group were significantly lower than those in the control group(P<0.05). After treatment,the mRNA levels of protein kinase R-like endoplasmic reticulum kinase(PERK),the α subunit of eukaryotic initiation factor 2(eif2α),glucose-regulated protein 78(GRP78),as well as the protein expression of p-PERK,p-eif2α,and GRP78 in the observation group were significantly lower than those in the control group. The mRNA and protein expressions of Beclin1,LC3 Ⅱ,and Bax were significantly lower,while the mRNA and protein expressions of Bcl-2 were significantly higher(P<0.05).[Conclusion] Maiguan Fukang capsule can improve neurological function in patients with ischemic stroke sequelae by improving cerebral arterial circulation,reducing blood viscosity,and alleviating inflammatory responses,and it inhibits the mRNA and protein expression of the endoplasmic reticulum stress-autophagy signaling pathway. |
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