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| Optimisation of the preparation of Verbena tablets by AHP-CRITIC empowerment method combined with BOX-Behnken response surface |
| Hits 185 Download times 70 Received:May 10, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2025.11.03 |
| Key Words
AHP-critic method;BOX-behnken response surface methodology;verbena officinalis;tablet;preparation process |
| Author Name | Affiliation | E-mail | | XIE Haonan | Tianjin University of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 301617, China
Tianjin University of Traditional Chinese Medicine, State Key Laboratory of Component-Based Chinese Medicine, Tianjin 301617, China
Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China | | | LIN Yun | Tianjin University of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 301617, China
Tianjin University of Traditional Chinese Medicine, State Key Laboratory of Component-Based Chinese Medicine, Tianjin 301617, China
Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China | | | LIU Yanling | Tianjin University of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 301617, China
Tianjin University of Traditional Chinese Medicine, State Key Laboratory of Component-Based Chinese Medicine, Tianjin 301617, China
Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China | | | JIAO Guorui | Tianjin University of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 301617, China
Tianjin University of Traditional Chinese Medicine, State Key Laboratory of Component-Based Chinese Medicine, Tianjin 301617, China
Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China | | | YANG Mengru | Tianjin University of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 301617, China
Tianjin University of Traditional Chinese Medicine, State Key Laboratory of Component-Based Chinese Medicine, Tianjin 301617, China
Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China | | | PI Ziyue | Tianjin University of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 301617, China
Tianjin University of Traditional Chinese Medicine, State Key Laboratory of Component-Based Chinese Medicine, Tianjin 301617, China
Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China | | | LIU Zhidong | Tianjin University of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Tianjin 301617, China
Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin 301617, China
Tianjin University of Traditional Chinese Medicine, State Key Laboratory of Component-Based Chinese Medicine, Tianjin 301617, China
Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China | lonerliuzd@163.com。 |
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| Abstract
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| [Objective] This study aimed to optimize the preparation process for Verbena tablets.[Methods] Through systematic screening of excipient types including fillers,disintegrants,and wetting agents,we established critical process parameters via single-factor experiments investigating drug loading,filler content,disintegrant proportion,and wetting agent quantity. Combined weight coefficients were calculated by integrating the AHP-CRITIC weighting method with the Box-Behnken response surface methodology.[Results] The optimized formulation was determined as 43.202% active pharmaceutical ingredient,29.213% filler,and 13.974% disintegrant,achieving a comprehensive evaluation score of 75.333. Validation experiments conducted in triplicate demonstrated good process stability,with average composite scores of 74.886,showing close agreement with predicted values. The optimized tablets exhibited satisfactory physical characteristics and stability profiles.[Conclusion] This investigation not only establishes a practical foundation for industrial production of Verbena tablets but also proposes an innovative methodology integrating multi-criteria decision analysis with quality-by-design principles for optimizing traditional Chinese medicine formulations. |
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