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| Research progress on nanoparticle-delivered active ingredients from traditional Chinese medicine for cancer therapy |
| Hits 352 Download times 210 Received:April 03, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2025.07.13 |
| Key Words
nanoparticle;active ingredient;cancer;drug delivery |
| Author Name | Affiliation | E-mail | | XU Yingyi | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Zigui | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin 301617, China | | | SHANG Ruipeng | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Qiang | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin 301617, China | | | DUAN Lili | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin 301617, China | | | QI Xuejie | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin 301617, China | qixuejie2014@163.com |
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| Abstract
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| Cancer remains a leading cause of global morbidity and mortality. Conventional chemotherapeutic agents often induce drug resistance and severe adverse effects. The advent of nanoparticles has introduced novel approaches for cancer diagnosis and treatment. Traditional Chinese medicine（TCM） with functions including activating blood circulation to resolve stasis，clearing heat-toxin，and replenishing qi-blood have demonstrated remarkable antitumor efficacy in clinical practice. However，the therapeutic potential of many TCM active components is limited by poor solubility and low bioavailability. Nanoparticle-based delivery systems can effectively overcome these pharmacological limitations. This review characterizes various types of nanoparticles，with particular emphasis on their applications for delivering TCM active components in cancer treatment. The findings may provide theoretical foundations for developing novel TCM nanomedicines and alternative strategies for cancer therapy. |
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