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| Systematic review and Meta-analysis of the efficacy and safety of promoting blood circulation and removing blood stasis in the treatment of mycoplasma pneumoniae pneumonia in children |
| Hits 358 Download times 179 Received:March 27, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2025.09.08 |
| Key Words
mycoplasma pneumoniae pneumonia;children;method of promoting blood circulation and removing blood stasis;Meta-analysis;systematic review |
| Author Name | Affiliation | E-mail | | WANG Haokai | Department of Pediatrics, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | YANG Shuo | Department of Pediatrics, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | XU Keying | Department of Pediatrics, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | FU Kunya | Department of Pediatrics, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | HAN Yaowei | Department of Pediatrics, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | LI Huanmin | Department of Pediatrics, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | LI Xinmin | Department of Pediatrics, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | tjtcmlxm@163.com |
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| Abstract
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| Objective To systematically evaluate the efficacy and safety of promoting blood circulation and removing blood stasis in the treatment of Mycoplasma pneumoniae pneumonia(MPP) in children, so as to provide evidence-based basis for clinical practice. Methods Cnki, Wanfang, VIP, CBM, Pubmed, Embase and Cochrane Library were searched by computer to collect all randomized controlled trials(RCTS) on the application of activating blood circulation, removing blood circulation and clearing collaterals in the treatment of MPP in children. The retrieval time was from the establishment of the database to September 1, 2024. Two researchers independently screened the literature, extracted data, and assessed the risk of bias of the included literature. Review Manager 5.4 software was used for Meta-analysis, and Stata14.0 software was used for sensitivity analysis. Results A total of 60 randomized controlled trials with 5 335 patients were included. The results of Meta-analysis showed that, compared with the control group, the application of promoting blood circulation and removing blood stasis combined with conventional western medicine treatment could effectively improve the clinical cure rate of children with MPP [RR=1.51, 95%CI(1.40, 1.62), P < 0.000 01], and shorten the days of complete antipyresis [MD=-1.43, 95%CI(-1.69, -1.16, P < 0.000 01), cough disappearance days [MD=-2.08, 95%CI(-2.42, -1.73), P < 0.000 01], lung rales disa-ppearance days [MD=-1.97, 95%CI(-2.25, -1.68), P < 0.000 01] length of hospital stay [MD=-1.82, 95%CI(-2.07, -1.57), P < 0.000 01];Reduce the C-reactive protein(CRP) of after treatment(MD=-3.15, 95%CI(-4.06, -2.24), P < 0.000 01), D-dimer [MD=-0.23, 95%CI(-0.39, -0.07), P=0.005], Interleukin-6(IL-6) [MD=-7.97, 95%CI(-8.51, -7.43), P < 0.000 01], Interleukin-8(IL-8) [MD=-6.24, 95%CI(-7.57, -4.91), P < 0.000 01];The total incidence of adverse reactions was reduced [RR=0.43, 95%CI(0.30, 0.62), P < 0.000 01], and the difference was statistically significant. Conclusion Promoting blood circulation and removing blood stasis combined with conventional western medicine treatment can clearly improve the clinical cure rate of MPP in children, shorten the days of complete antipyretic, cough disappearance, lung rall disappearance and hospitalization days, reduce the levels of CRP, IL-6, IL-8 and D-dimer in children with MPP after treatment, and reduce the total incidence of adverse reactions." |
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