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| Research progress in therapeutic role of glutamine metabolism in cancer and intervention of traditional Chinese medicine |
| Hits 372 Download times 138 Received:April 30, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2025.09.10 |
| Key Words
glutamine;metabolic reprogramming;cancer;Chinese medicine;research progress |
| Author Name | Affiliation | E-mail | | GU Yuanyuan | Institute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, China | | | FANG Fang | Department of Academic Theory Research, Heilongjiang University of Chinese Medicine, Harbin 150040, China | roseboat@163.com | | JIANG Shanshan | Department of Acupuncture, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150080, China | | | WANG Lianzhi | Institute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, China | | | TIAN Junjun | Department of Pharmacy, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China | | | PENG Youfei | Institute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, China | | | WANG Yue | Institute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, China | | | LI Yuanyuan | Institute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, China | |
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| Abstract
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| Metabolic reprogramming is one of the most important characteristics of cancer. Recent studies have shown that glutamine metabolism is involved in the malignant proliferation, invasion and metastasis of cancer cells, and also promotes the formation of new blood vessels in tumors, which is one of the important strategies to target cancer energy metabolism and has become a research hotspot in the field of anti-tumor. In recent years, it has been found that traditional Chinese medicine can participate in the tumorigenesis and development by regulating glutamine metabolism. Based on this, this paper reviewed the characteristics and regulatory mechanisms of glutamine metabolism in tumor cells, and discussed the intervention effect of traditional Chinese medicine on glutamine metabolism, which provided inspiration for targeting glutamine metabolism in the treatment of cancer. |
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