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Research progress of Bupleurum-Scutellaria baicalensis macrocephala herb pair and its active ingredients in the treatment of pulmonary diseases
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DOI   10.11656/j.issn.1673-9043.2025.09.11
Key Words   bupleuri radix-scutellaria herb pair;herb pairs;lung disease;mechanism of action;cinical efficacy
Author NameAffiliationE-mail
ZHAO Yiqing School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China  
CHEN Siyu School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China  
YANG Bin School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China yang3023008@163.com 
YANG Shenshen School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China shine2099@163.com 
Abstract
    Respiratory diseases are a kind of diseases whose main lesions are in trachea, bronchus and chest. At present, it has become one of the main causes of death in the world, which seriously threatens the quality of life of patients and brings certain economic burden. Traditional Chinese medicine believes that the pathogenesis of lung diseases can be divided into deficiency and excess, and the deficiency lies in the deficiency of qi and yin, but in the stagnation of qi, which is consistent with the pathological characteristics of shaoyang disease with deficiency and excess. Bupleuri Radix-Scutellaria herb pair is a common medicine pair in clinical practice of traditional Chinese medicine. It is the most representative basic compatibility in ZHANG Zhongjing's Chaihu series prescriptions, and it is also the basic structure of reconciliation of shaoyang. Many literatures reported that the prescription containing Bupleuri Radix-Scutellaria herb pair has good clinical efficacy in treating various lung diseases, but there is still a lack of systematic summary on the active components, pharmacological effects and mechanism of Bupleuri Radix Scutellaria herb pair in treating lung diseases. Therefore, taking lung diseases as the breakthrough point, this paper comprehensively summarizes the clinical applications, pharmacological effects, mechanism of action and drug safety of Bupleuri Radix-Scutellaria herb pair in treating lung diseases, laying a foundation for further discussing the dose-effect relationship of the combination and compatibility of Bupleuri Radix-Scutellaria herb pair and providing scientific basis for developing innovative Chinese medicine for preventing and treating various lung diseases.

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