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| Advances in the application of spatial metabolomics in toxicity research |
| Hits 324 Download times 148 Received:April 10, 2025 |
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| DOI
10.11656/j.issn.1673-9043.2025.09.13 |
| Key Words
spatial metabolomics;toxicity;traditional Chinese medicine;chemical drug;pesticide;environmental exposure |
| Author Name | Affiliation | E-mail | | DOU Yajie | School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Xiaoxuan | School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Xue | School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Xinyu | School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHAI Yujing | School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | QIN Xuebin | School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | XU Yanyan | School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | xyytjutcm@163.com | | WANG Yuming | School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | wangyuming226@163.com |
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| Abstract
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| Toxicity research holds an extremely significant position in the field of human health, relating to health risk assessment, drug development, public health, and food safety. Metabolomics has long been used as a technical means in toxicity research, revealing the metabolic response of the body in a high-throughput and static manner under toxic conditions. However, different regions of organs and tissues have different cellular compositions, leading to metabolic heterogeneity. Traditional metabolomics techniques cannot distinguish the heterogeneous distribution of metabolites in different micro-regions. Spatial metabolomics, based on the development of mass spectrometry imaging technology, fills the gap traditional metabolomics for in-situ visualization analysis. It combines high-resolution imaging technology with high-throughput metabolomics analysis, enabling precise measurement of the spatial distribution of metabolites within biological bodies. This provides a reliable tool for accurately locating toxic lesions and offers more possibilities for further revealing the mechanisms of toxicity. Therefore, this paper reviews the application of spatial metabolomics technology in the common toxicity research fields of traditional Chinese medicine, chemical drug toxicity, pesticide toxicity and chronic environmental pollutant exposure toxicity, focusing on the application status of spatial metabolomics in the toxicity study of traditional Chinese medicine, and analyzes the limitations of the current application of this technology, in order to provide a reference for promoting the application of spatial metabolomics in the field of toxicity research. |
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