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| Influence of Pingjiang Granule Combined with Nitrendipine on Vascoactive Peptides in Spontaneous Hypertensive Rats (SHR) |
| Hits 1595 Download times 1489 Received:March 26, 2002 |
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| DOI
10.11656/j.issn.1672-1519.2002.03.25 |
| Key Words
Pingjiang granule;Nitrendipine;SHR;CGRP;ET |
| Author Name | Affiliation | | Deng Xuguang | The Second People’s Hospital, Shenzhen 518031, China | | Lü Na | The Second People’s Hospital, Shenzhen 518031, China | | Xia Hongsheng | The Second People’s Hospital, Shenzhen 518031, China | | 金庆文 | The Second People’s Hospital, Shenzhen 518031, China | | 张永锋 | The Second People’s Hospital, Shenzhen 518031, China | | 吴少萍 | The Second People’s Hospital, Shenzhen 518031, China | | 黄铁军 | The Second People’s Hospital, Shenzhen 518031, China |
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| Abstract
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| Objective: To investigate the antihypertensive mechanism of Pingjiang Granule combined with Nitrendipine, protective effect for target organ, preventive and curative effect against hypertension complication. Methods: After four weeks of medicine, the concentration of calcitonin gene relative peptide(CGRP) in tissue, plasma and plasma endothelin (ET) level were examinated with radio-immunity assay in SHR,and compared with those in control group. Results: Plasma CGRP was higher in three treatment groups than in control group, while in hypothalamus and abdominal aortic artery was lower with statistic significance. Significant difference also existed between combined medicine group and western medicine group, Chinese medicine group separately.Plasma ET in three treatment groups was all lower than in control group and had statistic significance with the lowest value in combined group. Conclusion: Regulating and controlling the concentration of CGRP and ET in circulatory system are one of the mechanisms of antihypertensive effect of combined medicine, as well as the main mechanism of protecting target organs, and preventing and curing hypertension complication. The effect of combined medicine is markedly superior to that of single medicine. |
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